运动干预对肺癌患者健康相关生活质量影响的meta分析

Effect of exercise interventions on health-related quality of life in patients with lung cancer:a meta-analysis

目的系统评价运动干预对肺癌患者健康相关生活质量的影响。方法检索PubMed、Embase、Cochrane library、万方、中国知网等数据库,获取从数据库建立至2024年3月关于“运动干预对肺癌患者生活质量影响”的临床随机对照试验,对符合纳入标准的文献进行数据提取,应用STATA软件进行meta分析。结果最终纳入12项研究,共涉及333例患者。meta分析结果显示,运动训练可以提高肺癌患者的总体健康状况/生活质量[加权均数差(WMD)=6.70,95%置信区间(CI)2.49~10.90,P=0.002]及身体功能(WMD=1.78,95%CI 0.22~3.33,P=0.025),改善呼吸困难(WMD=-5.65,95%CI-8.62~-2.68,P<0.001)和疼痛症状(WMD=-8.26,95%CI-14.66~-1.87,P=0.011),但对患者的疲劳程度(WMD=-4.04,95%CI-8.76~0.69,P=0.094)无明显作用。结论运动干预可以有效提高肺癌患者的健康相关生活质量,未来需要更多的随机对照试验进一步验证。

Objective To systematically evaluate the effect of exercise interventions on health-related quality of life in patients with lung cancer.Methods A literature search was conducted on PubMed,Embase,Cochrane library,Wanfang,and CNKI databases until March 2024 for randomized controlled trials about effect of exercise interventions on health-related quality of life in patients with lung cancer.Data from studies meeting the inclusion criteria were extracted,and a meta-analysis was performed using STATA software.Results A total of 12 trials involving 333 patients were included.The results of meta-analysis showed that exercise interventions improved the overall health status/quality of life[weighted mean difference(WMD)=6.70,95%confidence interval(CI):2.49,10.90,P=0.002]and physical function(WMD=1.78,95%CI:0.22,3.33,P=0.025)of lung cancer patients,ameliorated dyspnea(WMD=-5.65,95%CI:-8.62,-2.68,P<0.001)and pain symptoms(WMD=-8.26,95%CI:-14.66,-1.87,P=0.011),but had no significant effect on patients'fatigue(WMD=-4.04,95%CI:-8.76,0.69,P=0.094).Conclusion Exercise interventions can effectively improve the health-related quality of life in patients with lung cancer,and more randomized controlled trials are needed to confirm these findings.