尿液TWIST1基因甲基化检测在膀胱癌术后监测中的价值

Value of urinary TWIST1 gene methylation detection in postoperative monitoring of bladder cancer

目的探索尿液TWIST1基因甲基化检测在膀胱癌术后复发监测中的预测作用。方法应用TWIST1基因甲基化试剂盒对接受经尿道膀胱肿瘤切除术治疗的51例非肌层浸润性膀胱癌患者进行随访复查,对比膀胱镜检查评估其价值,并对患者临床病理资料以及术后复发情况进行统计学分析。结果16例患者尿液TWIST1基因甲基化检测阳性,以同期膀胱镜检为标准,灵敏度达78.9%、特异度96.8%、阳性预测值93.7%、阴性预测值88.5%。结论尿液TWIST1基因甲基化检测可作为膀胱肿瘤患者电切术后复发的有效监测手段。

Objective To explore the predictive value of urinary TWIST1 gene methylation detection in postoperative recurrence monitoring of bladder cancer.Methods Fifty-one patients with non-muscle invasive bladder cancer who underwent transurethral resection of bladder tumor were followed up with TWIST1 gene methylation detection kit.The value of cystoscopy was evaluated,and the clinicopathological data and postoperative recurrence were statistically analyzed.Results Sixteen patients were detected to have TWIST1 gene methylation in urine.The sensitivity and specificity were 78.9%and 96.8%,respectively.The positive and negative predictive values were 93.7%and 88.5%,respectively,using cystoscopy as the standard.Conclusion Detection of TWIST1 gene methylation in urine can be used as an effective method to monitor the recurrence of bladder cancer after transurethral resection of bladder cancer.