基于“浊邪害清”理论探讨阿尔茨海默病中医药研究策略

Discussion on Chinese medicine research strategies of Alzheimer's disease based on theory of"turbid evils invading the clear orifice"

基于“浊邪害清”理论探讨阿尔茨海默病中医药研究策略。认为“浊邪害清”为该病中后期病情加重的核心病机,提出肾精亏虚为发病之基,痰瘀浊邪阻窍为发病的关键环节。结合临床研究及中药药理研究,认为补虚祛浊为其基本治则,提出在补肾生髓的基础上,配伍化痰开窍、活血祛瘀等核心治法。

The research strategy of traditional Chinese medicine in Alzheimer's disease(AD)is discussed based on the theory of"turbid evils invading the clear orifice".It is believed that"turbid evils invading the clear orifice"is the core mechanism for the aggravation of the disease in the middle and late stages.It is proposed that deficiency of kidney essence is the basis of pathogenesis,and phlegm and stasis evils obstruction of the orifice is the key link of pathogenesis.Combined with clinical research and Chinese medicine pharmacology research,it is believed that tonifying deficiency and dispelling turbidity is the basic rule of treatment,and it is proposed that on the basis of tonifying the kidney and generating the marrow,the core treatments such as resolving phlegm and opening orifice,activating blood circulation and dispelling blood stasis should be combined.