调神养心汤治疗围绝经期失眠的临床效果观察

Observation on the clinical effect of Tiaoshen Yangxin decoction in treating insomnia during perimenopause

目的观察调神养心汤治疗心肾不交型围绝经期失眠患者的临床效果。方法选取2022年7月至2023年7月于浙江省立同德医院就诊的符合诊断标准的60例心肾不交型围绝经期失眠患者。采用随机数字表法将患者分为对照组和试验组,每组30例。对照组患者采用乌灵胶囊治疗,试验组患者采用调神养心汤治疗。比较两组患者治疗前、治疗后第8周的匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分、Kupperman绝经指数(Kupperman menopause index,KMI)评分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分及中医证候积分。结果治疗8周后,试验组患者的总有效率达96.7%,高于对照组的86.7%(χ^(2)=17.153,P=0.000);试验组患者的潮热及出汗、失眠、心悸等症状评分低于对照组(P<0.05);试验组患者治疗后的HAMA评分与中医证候积分低于对照组(P<0.05)。结论调神养心汤对围绝经期失眠患者的疗效优于乌灵胶囊。此外,调神养心汤还可改善围绝经期失眠患者的潮热、出汗、心悸等症状,缓解焦虑情绪。

Objective To observe the clinical effect of Tiaoshen Yangxin decoction on insomnia in perimenopausal patients with heart-kidney disharmony type.Methods From July 2022 to July 2023,60 patients with perimenopausal insomnia of heart-kidney disharmony type who met the diagnostic criteria were selected from Tongde Hospital of Zhejiang Province.The patients were divided into control group and experimental group by random number table method,30 cases in each group.The patients in control group were treated with Wuling capsule,and the patients in experimental group were treated with Tiaoshen Yangxin decoction.Before treatment and 8 weeks after treatment,the Pittsburgh sleep quality index(PSQI)score,Kupperman menopause index(KMI)score,Hamilton anxiety scale(HAMA)and TCM syndrome score were compared between two groups.Results After 8 weeks of treatment,the total effective rate of experimental group patients was 96.7%,which was higher than that of control group’s 86.7%(χ^(2)=17.153,P=0.000);The scores of the symptom of hot flashes,sweating,insomnia,palpitations,etc.in experimental group patients were lower than those in control group(P<0.05);The HAMA score and TCM syndrome score of experimental group patients after treatment were lower than those of control group(P<0.05).Conclusion The curative effect of Tiaoshen Yangxin decoction on insomnia in perimenopausal patients is better than that of Wuling capsule.In addition,Tiaoshen Yangxin decoction can also improve the symptoms of hot flashes,sweating,palpitations in perimenopausal insomnia patients and relieve anxiety.