中药干预JAK/STAT信号通路防治脓毒症的研究进展

Research progress on the prevention and treatment of sepsis by intervening in JAK/STAT signaling pathway with traditional Chinese medicine

脓毒症是一种由感染引发的危及生命的器官功能障碍,Janus激酶/信号转导和转录激活因子(JAK/STAT)信号通路在其中起着关键作用,参与了炎症反应、氧化应激和细胞凋亡的调控。一些中药单体,如黄酮类(如紫杉叶素等)、生物碱类(如青藤碱等)、二苯乙烯类(如白皮杉醇等)能通过调控JAK/STAT信号通路发挥抗炎、抗氧化、抑制细胞凋亡等作用,有助于改善脓毒症。中药复方(如左金方)和中药注射剂(如黄芪注射液、血必净注射液等)也能通过抑制JAK/STAT信号通路,抑制炎症反应和保护器官功能,减轻脓毒症相关损伤。尽管中药在脓毒症防治中显示出巨大潜力,但目前的研究主要集中在体外实验和动物实验,有待开展更多相应临床研究。

Sepsis is a life-threatening organ dysfunction caused by infection.Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway plays a key role in the regulation of inflammatory response,oxidative stress and apoptosis.Some traditional Chinese medicine monomers,such as flavonoids(such as taxifolin),alkaloids(such as sinomenine),and stilbenes(such as piceatannol)can exert anti-inflammatory,anti-oxidation,and inhibition of apoptosis by regulating the JAK/STAT signaling pathway,which is helpful to improve sepsis.Traditional Chinese medicine compounds(such as Zuojinfang)and traditional Chinese medicine injections(such as Astragalus injection,Xuebijing injection)can also inhibit inflammation,protect organ function,and reduce sepsis-related damage by regulating JAK/STAT signaling pathway.Although traditional Chinese medicine has shown great potential in the prevention and treatment of sepsis,the current research mainly focuses on in vitro and animal models,and more relative clinical researches need to be conducted.