CT纹理分析技术在肺腺癌患者靶向治疗效果评估中的应用价值及参数分析

The application value and parameter analysis of CT texture analysis technology in targeted therapy evaluation of lung adenocarcinoma patients

目的:探讨CT纹理分析技术在肺腺癌患者靶向治疗效果评估中的应用价值并分析相关参数。方法:选择2022年7月—2023年6月烟台市福山区人民医院97例靶向治疗的肺腺癌患者,通过CT纹理分析技术进行诊断分析并获取相关参数,根据靶向治疗效果分为治疗有效组、治疗无效组,比较两组CT纹理分析技术参数,分析其在肺腺癌患者靶向治疗效果评估中的应用价值。结果:埃克替尼治疗后3个月,0例完全缓解,39例部分缓解,34例疾病稳定,24疾病进展,治疗无效占59.79%(58/97)。两组偏度、熵比较,差异无统计学意义(P>0.05),治疗无效组逆差距、平均灰度值高于治疗有效组,差异有统计学意义(P<0.05)。CT纹理分析参数逆差距、平均灰度值在肺腺癌患者靶向治疗效果评估中的曲线下面积分别为0.772、0.853,均有一定预测价值。结论:CT纹理分析技术在肺腺癌患者靶向治疗效果评估中具有重要的应用价值。通过对逆差距和平均灰度值等参数的分析,可以帮助评估治疗效果,有助于临床医生指导肺腺癌患者的靶向治疗策略制定和调整。

Objective To explore the application value and analysis of relevant parameters of CT texture analysis technology in the evaluation of targeted therapy efficacy in lung adenocarcinoma patients.Methods 97 lung adenocarcinoma patients treated with targeted therapy in Yantai Fushan District People's Hospital from July 2022 to June 2023 were selected.CT texture analysis technology was used for diagnostic analysis and relevant parameters were obtained.According to the effectiveness of targeted therapy,they were divided into effective and ineffective groups.The parameters of CT texture analysis technology were compared between the two groups,and their application value in the evaluation of targeted therapy effectiveness in lung adenocarcinoma patients was analyzed.Results Three months after Icotinib treatment,there were 0 case of complete remission,39 cases of part remission,34 cases of stable disease,24 cases of progressive disease,with ineffective treatment accounting for 59.79%(58/97).There was no significant difference in skewness and entropy between the two groups(P>0.05).The deficit distance and average gray value of the ineffective treatment group were higher than those of the effective treatment group,the difference was statistically significant(P<0.05).The AUC values of deficit distance and average gray value of CT texture analysis parameters in the evaluation of targeted therapy effect of lung adenocarcinoma patients were 0.772 and 0.853,respectively,which had certain predictive value.Conclusion CT texture analysis technology has important application value in the evaluation of the efficacy of targeted therapy for lung adenocarcinoma patients.The analysis of parameters such as gap distance and average gray value can help evaluate the effectiveness of treatment,and help clinicians guide the formulation and adjustment of targeted therapy strategies for lung adenocarcinoma patients.