双酚类污染物对肠道损伤的作用及机制研究

Studies on the role and mechanism of intestinal damage by bisphenol pollutants

双酚类物质作为一类常用的工业原料,在许多行业中被广泛用作添加剂,特别是在食品包装、罐头食品、玩具、塑料和牙科密封剂等一些日常消费品的生产中,但与此同时,人类经口暴露于双酚类物质的风险也在与日俱增.由于目前针对双酚类污染物的研究大多集中在内分泌系统、神经系统、生殖系统及免疫系统,有关其对消化系统损伤效应的研究仍十分匮乏,因此,开展非雌激素受体介导的肠道功能损伤研究,是探究环境中双酚类物质暴露对肠道疾病发病潜在影响的迫切需求.本课题组将关键解决环境剂量水平下的双酚类污染物体内代谢全过程与肠上皮屏障功能损伤的关联机制,进一步重点阐明双酚类污染物是否通过扰动腺苷代谢信号、引发肠道屏障功能障碍作为起始性的关键步骤,进而影响肠道疾病的发病风险.

Bisphenols,as common industrial raw materials,are widely used as additives in many industries,especially in the production of a number of daily consumer products such as food packaging,canned foods,toys,plastics,and dental sealants.However,the risk of oral exposure of human beings to bisphenols is increasing.Since most of the current research on bisphenol pollutants focuses on the endocrine,nervous,reproductive,and immune systems,there is still a lack of research on their damaging effects on the digestive system.Therefore,studies on non-estrogen receptormediated impairments of intestinal function are urgently needed to investigate the potential effects on the pathogenesis of intestinal diseases.This work will critically address the mechanisms linking in vivo metabolism of bisphenol pollutants to the impairment of intestinal epithelial barrier at environmental exposure levels.And further focus was placed on elucidating whether bisphenol pollutants affect the risk of intestinal diseases by perturbing adenosine metabolic signaling and triggering intestinal barrier dysfunction as an initiating critical step,which in turn affects the risk of intestinal diseases.