银杏叶提取物在抗动脉粥样硬化中的机制及临床应用进展

Progress in mechanism and clinical application of ginkgo biloba extract in anti-atherosclerosis

银杏叶提取物作为中国传统中药具有抗炎症、抗氧化、维持细胞生存、抑制血小板活化、扩张血管以及调节代谢等作用,广泛应用于临床治疗多种心血管疾病,尤其是动脉粥样硬化。在动脉粥样硬化治疗中,银杏叶提取物可以通过作用于5′-磷酸腺苷活化蛋白激酶-蛋白激酶B、丝裂原活化蛋白激酶、磷脂酰肌醇-3-激酶-蛋白激酶B、核因子E2相关因子-血红素加氧酶1多种通路发挥保护效应。本文对银杏叶提取物治疗动脉粥样硬化的机制及临床应用作一综述。

Ginkgo biloba extract(GBE),as a traditional Chinese medicine,has the functions of anti-inflammation,anti-oxidation,maintaining cell survival,inhibiting platelet activation,dilating blood vessels and regulating metabolism.It is widely used in clinical treatment of a variety of cardiovascular diseases,especially atherosclerosis.In the treatment of atherosclerosis,GBE can play a protective effect by acting on multiple pathways including 5′-adenosine monophosphate-activated protein kinase/protein kinase B,mitogen-activated protein kinase,phosphatidylinositol-3-kinase/protein kinase B,nuclear factor E2-related factor/heme oxygenase-1.This article reviews the mechanism and clinical application of GBE in the treatment of atherosclerosis.