依托咪酯联合丙泊酚诱导麻醉应用于抑郁症患者无抽搐电休克治疗中的有效性和安全性分析

Efficacy and Safety Analysis of Etomidate Combined with Propofol In⁃duced Anesthesia in the Treatment of Non-convulsive Electroconvulsive in Patients with Depression

目的探讨抑郁症患者在无抽搐电休克治疗中采用依托咪酯联合丙泊酚诱导麻醉的有效性和安全性。方法随机选取2021年3月—2023年12月广东省江门市新会区第三人民医院收治的90例抑郁症患者为研究对象,按照不同麻醉诱导方案分组,分别命名为A组、B组、C组,每组30例,3组在无抽搐电休克治疗中分别采用丙泊酚、依托咪酯、依托咪酯联合丙泊酚,对比3组麻醉诱导前后的生命体征、呼吸恢复时间、苏醒时间、抽搐持续时间、抽搐能量指数、氧化应激指标和不良反应发生率。结果麻醉诱导后,在舒张压、收缩压、心率、血氧饱和度的比较上,C组均高于A组与B组,差异有统计学意义(P均<0.05)。C组呼吸恢复时间(7.76±1.61)min、苏醒时间(10.34±2.32)min均短于A组[(8.98±2.53)min、(13.85±3.33)min]与B组[(8.95±2.46)min、(13.74±3.28)min],差异有统计学意义(F=2.217、4.635,P均<0.05)。C组抽搐持续时间长于A组与B组,且抽搐能量指数高于A组与B组,差异有统计学意义(P均<0.05)。治疗后,C组超氧化物歧化酶和过氧化氢酶均高于A组与B组,差异有统计学意义(P均<0.05)。3组不良反应发生率比较,差异无统计学意义(P>0.05)。结论抑郁症患者在无抽搐电休克治疗中采用依托咪酯联合丙泊酚诱导麻醉的效果较显著,不仅可以有效稳定其生命体征,缩短其恢复时间,还可以改善其抽搐情况,减轻其氧化应激反应,且安全性良好。

Objective To investigate the efficacy and safety of etomidate combined with propofol in non-convulsive electroconvulsive therapy for patients with depression.Methods A total of 90 patients with depression who were admit⁃ted in the Guangdong Jiangmen Xinhui District Third People's Hospital from March 2021 to December 2023 were ran⁃domly selected as the research objects.According to different anesthesia induction schemes,they were divided into group A,group B and group C,with 30 cases in each group.Propofol,etomidate and etomidate combined with propofol were used in the treatment of non-convulsive electroconvulsive therapy.The vital signs,respiratory recovery time,re⁃covery time,convulsion duration,convulsion energy index,oxidative stress index and incidence of adverse reactions before and after anesthesia induction were compared among the three groups.Results After anesthesia induction,the diastolic blood pressure,systolic blood pressure,heart rate and oxygen saturation in group C were higher than those in group A and group B,and the differences were statistically significant(all P<0.05).The respiratory recovery time was(7.76±1.61)min and recovery time was(10.34±2.32)min in group C,which were shorter than those in group A[(8.98±2.53)min,(13.85±3.33)min]and group B[(8.95±2.46)min,(13.74±3.28)min],the differences were statistically sig⁃nificant(F=2.217,4.635,both P<0.05).The duration of convulsion in group C was longer than that in group A and group B,and the convulsion energy index was higher than that in group A and group B,the differences were statisti⁃cally significant(all P<0.05).After treatment,superoxide dismutase and catalase in group C were higher than those in group A and group B,and the differences were statistically significant(all P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion Etomidate combined with propofol can induce anesthesia significantly in non-convulsive electroconvulsive therapy for depression patients,which can not only effectively stabilize their vital signs,shorten their recovery time,but also improve their convulsions and reduce their oxidative stress response,with good safety.