健脾益肾方联合耳穴压豆治疗中枢性性早熟痰湿壅滞证临床研究

Clinical Study on Jianpi Yishen Prescription Combined with Auricular Point Seed-Pressing for Central Precocious Puberty with Phlegm-Damp Stagnation Syndrome

目的:观察健脾益肾方联合耳穴压豆治疗中枢性性早熟(CPP)痰湿壅滞证的临床疗效。方法:将2021年4月—2022年6月收治的符合纳入标准的CPP痰湿壅滞证女童84例,随机分为研究组和对照组各42例,对照组给予皮下注射醋酸亮丙瑞林治疗,研究组在对照组治疗方案的基础上给予健脾益肾方联合耳穴压豆治疗。治疗6个月后比较2组临床疗效、中医证候积分、生长发育情况、第二性征指标和性激素水平。结果:治疗后,2组中医证候积分、体质量指数(BMI)、骨龄差、子宫容积、卵巢容积、乳核指数均较治疗前降低,差异均有统计学意义(P<0.05);且研究组中医证候积分、BMI、骨龄差、子宫容积、卵巢容积、乳核指数均低于对照组,差异均有统计学意义(P<0.05)。2组黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E_(2))水平均较治疗前降低,差异均有统计学意义(P<0.05),且研究组LH、FSH、E_(2)水平均低于对照组,差异均有统计学意义(P<0.05)。研究组临床疗效总有效率高于对照组,差异有统计学意义(P<0.05)。结论:健脾益肾方联合耳穴压豆治疗可进一步提高CPP痰湿壅滞证的临床疗效,调节患儿生长发育。

Objective:To observe the clinical effect of Jianpi Yishen Prescription combined with auricular point seed-pressing on central precocious puberty(CPP)with phlegm-damp stagnation syndrome.Methods:A total of 84 girls with CPP with phlegm-damp stagnation syndrome who met the inclusion criteria and were admitted from April 2021 to June 2022 were randomly divided into the study group and the control group,with 42 cases in each group.The control group was treated with subcutaneous injection of Leuprorelin Acetate,and the study group was treated with Jianpi Yishen Prescription combined with auricular point seed-pressing on the basis of the treatment plan of the control group.Compared the clinical efficacy,traditional Chinese medicine syndrome scores,growth and development status,secondary sexual characteristic indicators,and sex hormone levels between the two groups after six months of treatment.Results:After treatment,the traditional Chinese medicine syndrome scores,body mass index(BMI),bone age difference,uterine volume,ovarian volume,and breast nucleus indexes in both groups were decreased when compared with those before treatment,differences being significant(P<0.05);the traditional Chinese medicine syndrome score,BMI,bone age difference,uterine volume,ovarian volume,and breast nucleus index in the study group were all lower than those in the control group,differences being significant(P<0.05).The levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),and estradiol(E_(2))in both groups were declined when compared with those before treatment,differences being significant(P<0.05);the LH,FSH,and E_(2)levels in the study group were lower than those in the control group,differences being significant(P<0.05).The total effective rate of clinical efficacy in the study group was higher than that in the control group,and the difference was significant(P<0.05).Conclusion:The combination of Jianpi Yishen Prescription combined with auricular point seed-pressing can further improve the clinical efficacy of CPP with phlegm-damp stagnation syndrome and regulate the growth and development of children.