抗痛风药及利尿剂电化学检测研究综述

A Review of Electrochemical Detection of Anti-gout Drugs and Diuretics

抗痛风药及利尿剂的检测分析具有重要的理论价值和实际意义。最近15年,以脉冲技术(DPV、SWV)和溶出伏安分析(ASV)为主的电化学方法在此类药物检测中发挥了重要作用,成效显著。但是,上述分析手段在应用过程中仍存在电极制备缺乏原位表征、修饰材料组装过于粗放、检测效率有待提升等局限。整个研究领域呈现出不均衡现象,如抗痛风药检测研究相对薄弱、传感器类型与电极修饰材料较为单一、对高效能检测技术关注不足、复杂组分(药物联用)分析欠缺等。面对未来“准确、高效、智能”的检测需求,预计今后的研究将聚焦于电化学检测与光谱学分析联用、“特殊结构纳米材料+分子印迹膜”复合物使用、机器学习及智能手机辅助应用等三个方面。

The detection and analysis of anti-gout drugs and diuretics are of great theoretical value and practical significance.In the past 15 years,electrochemical methods including pulse technology(DPV.SWV)and stripping voltammetry(ASV)have played an important role in the detection of the drugs,and the results have been remarkable.However,there are still some limitations in the application of above methods,such as lack of in-situ characterization in electrode preparation,extensive assembly of modifiers,low efficiency.Meanwhile,the research in the whole field is unbalanced.For example,research on anti-gout drugs is comparatively weak,sensor type and electrode modification material are of single variety,high performance detection method is less concerned,analysis of complex components is deficient.To meet the requirements of accurate,efficient and intelligent detection,it is predicted that future research will focus on three aspects:coupling electrochemical determinations with spectroscopic analysis,the use of composites based on nanomaterials with special structures and molecularly imprinted polymers,and machine learning and smartphone-assisted application.