银屑病合并抑郁症的发病机制及治疗现状

Pathogenesis and Current Treatment Status of Psoriasis and Comorbid Depression

银屑病是一种免疫相关的慢性复发性疾病,患者常因病情反复和迁延不愈而产生焦虑、抑郁等心理问题,进而加重病情及治疗经济负担。银屑病患者是抑郁症的高风险人群,抑郁症也是导致银屑病发生的危险因素。二者具有重叠的致病途径,但具体机制尚待阐明。现阶段针对银屑病的抗炎治疗、认知行为疗法和精神药物治疗已经被证实,不仅能够改善患者皮损,还可同时减轻共患抑郁症的严重程度。本文重点阐述银屑病合并抑郁症的流行病学现状、发病机制及治疗策略,为进一步提高银屑病合并抑郁症的综合管理水平提供参考。

Psoriasis is an immune-related chronic relapsing disease.Patients with psoriasis often experience anxiety,depression,and other psychological issues due to the recurrent and prolonged nature of the disease,exacerbating the condition and increasing the economic burden of treatment.Psoriasis patients are at high risk for depression,which is also a risk factor for the onset of psoriasis.Both conditions share overlapping pathogenic pathways,although the specific mechanisms remain to be elucidated.Current anti-inflammatory treatments for psoriasis,cognitive-behavioral therapy,and psychopharmacological treatments have been proven to not only improve skin lesions but also alleviate the severity of comorbid depression.This paper focuses on the epidemiological status,pathogenesis,and treatment strategies of psoriasis comorbid with depression,providing references for improving the comprehensive management of this condition.