摘要
肝缺血再灌注损伤(IRI)是肝移植、肝切除等外科手术后肝功能衰竭的重要原因,其发生机制与氧化应激及免疫反应密切相关,但目前仍缺乏有效的防治手段。经肠道菌群发酵产生的短链脂肪酸是人体内短链脂肪酸的主要来源,研究发现,其在氧化应激及免疫应答中扮演重要角色。本文主要介绍肠道菌群主要代谢产物短链脂肪酸在肝IRI中的研究进展,以期为肝IRI的防治策略提供参考。
Liver ischemia-reperfusion injury(IRI)is a significant factor contributing to liver dysfunction following surgical procedures such as liver transplantation and hepatectomy,and its pathogenesis is closely associated with oxidative stress and immune responses.However,effective prevention and therapeutic strategies are still lacking.Short-chain fatty acids(SCFAs),primarily produced by the fermentation of gut microbiota,are the major source of these acids in the human body.Research has indicated that SCFAs play a significant role in oxidative stress and immune response.This review primarily focuses on the advancements on the role of SCFAs,the main metabolic byproducts of gut microbiota,in liver IRI,with a view to provide insights for the development of prevention and treatment strategies for liver IRI.
作者
徐文静
侯文
杨爽
卢建森
陈德成
王菲
刘蕾
Xu Wenjing;Hou Wen;Yang Shuang;Lu Jiansen;Chen Decheng;Wang Fei;Liu Lei(The First Central Clinical School,Tianjin Medical University,Tianjin 300070,China;Research Institute of Transplant Medicine,Nankai University,Tianjin 300071,China;NHC Key Laboratory for Critical Care Medicine,Tianjin First Central Hospital,Tianjin 300073,China;Emergency Critical Care Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China;Nankai University Medical College,Tianjin 300071,China;Department of Organ Transplantation,Tianjin First Central Hospital,Tianjin 300192,China)
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2024年第10期787-790,共4页
Chinese Journal of Hepatobiliary Surgery
基金
天津市自然科学基金(20JCYBJC00980)。
关键词
肝
缺血再灌注损伤
短链脂肪酸
氧化应激
免疫反应
Liver
Ischemia-reperfusion injury
Short-chain fatty acids
Oxidative stress
Immune responses
