血清高尿酸在2型糖尿病合并肌少症中的作用

Roles of serum hyperuricemia in type 2 diabetes mellitus complicated with sarcopenia

2型糖尿病合并肌少症是一种以高血糖与骨骼肌质量功能低下为主要表现的疾病,严重影响老年人的总体健康和生活质量。近来的研究表明,血清高尿酸是2型糖尿病患者肌肉量减少的独立危险因素。进一步研究证实,高水平的血清尿酸具有刺激炎症因子生成、促进氧化应激发生、阻碍线粒体和内皮的正常功能以及诱导胰岛素抵抗等特性。本文回顾了该领域的相关文献,对血清高尿酸在2型糖尿病合并肌少症发生发展中的作用进行综述,以期为2型糖尿病合并肌少症治疗提供新的思路与靶点。

Type 2 diabetes mellitus with sarcopenia is a disease characterized by high blood glucose and low skeletal muscle mass function,which seriously affects the overall health and quality of life of the elderly.Recent studies have shown that high serum uric acid is an independent risk factor for muscle mass loss in patients with type 2 diabetes.Further studies have confirmed that high levels of uric acid have the properties of stimulating the production of inflammatory factors,promoting oxidative stress,hindering the normal function of mitochondria and endothelium,and inducing insulin resistance.This paper reviews the relevant literature in this field and summarizes the role of serum hyperuricemia in the occurrence and development of type 2 diabetes mellitus combined with sarcopenia,in order to provide new ideas and targets for the treatment of type2 diabetes mellitus combined with sarcopenia.