STAT1在抗病毒天然免疫中的作用

Function of STAT1 in antiviral innate immunity

信号传导与转录激活因子1(signal transducers and activators of transcription 1,STAT1)是Janus激酶(Janus kinase,JAK)-STAT通路中的关键分子之一,在宿主抗病毒天然免疫反应中发挥重要作用。在抗病毒免疫信号传导过程中,STAT1能够形成同源二聚体或与STAT2形成异源二聚体并转移至细胞核中,激活多种干扰素刺激基因的转录,最终发挥抗病毒作用。本文综述了病毒感染后STAT1的激活过程、宿主或病毒编码的蛋白对STAT1的作用以及调控STAT1的药物研究进展,为进一步研究STAT1在抗病毒和病毒感染中的作用提供理论参考。

Signal transducers and activators of transcription 1(STAT1)is one of the key molecules in Janus kinase(JAK)-STAT pathway and plays an important role in innate antiviral immune response.In the process of antiviral immune signal transduction,STAT1 can form homodimers or heterodimers with STAT2 and transfer to the nucleus,enhance the transcription of interferon stimulated genes,and ultimately play an antiviral role.This review summarizes the activation process of STAT1 after virus infection,the effect of host or virus encoded proteins on STAT1,and the research progress of STAT1 regulation drugs,which provide theoretical reference for further research on the role of STAT1 in antiviral and viral infection.