电纺膜微观形貌对骨髓间充质干细胞生物学行为的影响

Effect of electrospun membrane morphology on biological behavior of bone marrow mesenchymal stem cells

目前,材料物理因素对细胞的影响是研究热点之一。相关研究显示,静电纺丝所制备的支架材料所具有的微观形貌显著影响骨髓间充质干细胞(Bone marrow mesenchymal stem cell,BMSC)在其上的生物学行为,这些形貌因素包括纤维直径、纤维排列方式、孔径与孔隙率等。本综述着重讨论了静电纺丝支架材料的微观形貌因素对BMSC生物学行为的影响,以期为静电纺丝支架材料的物理因素设计提供参考。

At present,the influence of material physical factors on cell fate is one of the research hotspots.Relevant studies have shown that the microscopic morphology of scaffolds prepared by electrospinning significantly affects the biological behavior of bone marrow mesenchymal stem cells(BMSC),such as fiber diameter,fiber arrangement,pore size and porosity.This review focused on the effect of the micromorphology of electrospinning scaffold materials on the biological behavior of BMSC,in order to provide reference for the design of physical factors of electrospinning scaffold materials.