氧化铈纳米颗粒在创面修复中的应用

Application of cerium oxide nanoparticles in wound healing

创面愈合是一个复杂的生理过程,主要分为止血、炎症、增殖和迁移、组织重塑这四个阶段,涉及肉芽形成、炎性细胞浸润、坏死组织清理、瘢痕重塑等一系列反应。在一些病理情况下,创面的自然愈合过程可能会停滞,造成病情反复发作甚至导致患者休克死亡。近年来,寻找高安全性、高效率的医药材料的研究备受关注。其中,氧化铈纳米颗粒是一种独特的促创面愈合材料,可在伤口愈合的各阶段都发挥重要作用。氧化铈纳米颗粒不仅具备抗氧化、抗菌、抗炎症的功能,还可以在创面修复中作为药物载体以确保机体的良性吸收,同时可作为组织支架促进新生结构发育成熟。因此,探索伤口愈合过程中氧化铈纳米颗粒的作用可能成为创面修复的新策略。本文对氧化铈纳米颗粒在创面修复中的作用进行综述,为其在未来的进一步应用及开发提供借鉴。

Wound healing is a complex physiological process, which can be divided into four main stages: Hemostasis, inflammation, proliferation and migration, and tissue remodeling. At the same time, granulation formation, inflammatory cell infiltration, necrotic tissue cleaning, scar remodeling and other reactions are involved. In some pathological cases, the natural healing process of the wound may be stalled, resulting in repeated attacks and even death from shock. In recent years, the search for high safety and high efficiency medical materials has attracted much attention from researchers. Among them, cerium oxide nanoparticles are a unique material which can promote wound healing and play an important role in all stages of wound healing. Nano-cerium oxide particles not only have antioxidant, antibacterial and anti-inflammatory functions, but also can be used as drug carriers in wound repair to ensure the benign absorption of the body, and can be used as tissue scaffolds to promote the development and maturity of new structures. Therefore, exploring the role of cerium oxide nanoparticles in wound healing may be a new strategy for wound repair. In this paper, the effects of cerium oxide nanoparticles on wound repair were reviewed to provide references for their further application and development in the future.