实体器官移植术后谵妄的研究进展

Research progress of delirium after solid organ transplantation

实体器官移植术后谵妄作为影响器官移植受者预后的重要因素,目前缺乏足够的临床关注。其病理生理机制尚不明确,与移植器官的种类、受者年龄、血糖变异、大剂量糖皮质激素冲击治疗等有着紧密的联系。明确实体器官移植术后谵妄发生的危险因素并及早进行干预,对改善患者预后至关重要。本文通过综述国内外近年实体器官移植术后谵妄相关文献,明确术后谵妄的定义、分类、临床表现和诊断标准,汇总实体器官移植术后谵妄的危险因素,着重突出实体器官移植受者区别于其他患者的特点,并总结其预后和防治方法,旨在提升临床对实体器官移植术后谵妄的关注度,改善受者预后。

Delirium after solid organ transplantation is an important factor affecting the prognosis of organtransplant recipients,but it lacks sufficient clinical attention at present.The pathophysiological mechanisms are not yetclear,which are closely related to the type of transplant organ,recipient's age,blood glucose variability,high-doseglucocorticoid therapy,and other factors.It is crucial to identify and early intervene the risk factors for delirium after solidorgan transplantation for improving patients’prognosis.This article reviewed the literature on delirium after solid organtransplantation in recent years at home and abroad,clarified the definition,classification,clinical manifestations,anddiagnostic criteria of postoperative delirium,summarized the risk factors for delirium after solid organ transplantation,highlighted the characteristics of transplant recipients that are different from other patients,and summarized theirprognosis and prevention and treatment methods.The aim is to enhance clinical attention to delirium after solid organtransplantation and improve the prognosis of recipients.