铁死亡相关机制及其在肿瘤治疗中的应用

Ferroptosis:Mechanisms and Application in Tumor Treatment

铁死亡是一种依赖于铁和活性氧的调节性细胞死亡方式,主要特征是细胞内脂质过氧化物堆积,与细胞凋亡、坏死和自噬不同。研究发现,铁死亡与肿瘤发生发展密切相关,可以通过诱导肿瘤细胞铁死亡来提高治疗药物对肿瘤的抑制效果。本文就铁死亡的发生机制以及铁死亡与肿瘤相关研究的最新进展进行总结,以期为深入理解铁死亡与肿瘤之间的作用机制提供参考,并为肿瘤治疗策略提供新的思路和潜在靶点。

Ferroptosis is a form of regulated cell death that depends on iron and reactive oxygen species.Different from apoptosis,necrosis,and autophagy,ferroptosis is characterized by the accumulation of lipid peroxides in cells.Studies have discovered that ferroptosis is closely associated with the occurrence and development of tumors and inducing ferroptosis in tumor cells can enhance the therapeutic effects of drugs on tumors.This article summarizes the latest research progress in ferroptosis regarding its mechanisms and associations with tumors,aiming to provide a reference for further understanding the interaction mechanisms between ferroptosis and tumors and offering new insights and targets for the treatment of tumors.