血管内激光消蚀的研究进展

Advances in Intravascular Laser Atherectomy

据推算,目前在中国地区心血管病的患病人数已达到3.3亿,其中冠心病患者约1139万,下肢动脉疾病患者达4530万,心血管病和外周动脉疾病的治疗相关医疗器械潜在市场较大。其中,经皮动脉介入治疗已成为冠心病和下肢动脉疾病最常见的治疗手段之一,但该方法在处理如高阻力病变等复杂病变时仍面临巨大挑战。血管内激光消蚀技术以其精确移除或改变病变组织的能力,在处理动脉内复杂病变上显示出独特的优势。文章全面综述了激光消蚀技术的作用机制以及全球市场上主要的血管内激光消蚀系统,并详细探讨了相关产品的技术参数。此外,文章还比较了不同系统在光化学、光热和光机械效应方面的表现,明确了各技术之间的关键差异以及其临床应用情况。

It is estimated that the prevalence of cardiovascular diseases has reached 330 million people in China,with approximately 11.39 million coronary artery disease patients and 45.3 million peripheral arterial disease patients.The potential market for medical devices related to the treatment of cardiovascular disease and peripheral arterial disease is relatively large.Percutaneous arterial intervention has become the most common treatment method for coronary artery and lower limb arterial diseases.However,this approach still faces significant challenges when dealing with complex lesions such as high-resistance lesions.Intravascular laser atherectomy,with its precise capability to remove or alter lesioned tissue,has shown unique advantages in treating complex arterial lesions.This article comprehensively reviews the mechanisms of action of laser atherectomy and the major intravascular laser atherectomy systems on the global market,with a detailed discussion of the technical parameters of the related products.Moreover,the article compares different systems in terms of photochemical,photothermal,and photomechanical effects,clearly identifying key differences between the technologies and their clinical applications.