乳腺浸润性导管癌的超声特征及与血清α1-抗胰蛋白酶、环氧合酶-2、癌抗原153的相关性

Ultrasound Characteristics of Invasive Ductal Carcinoma of the Breast and Its Correlation with Serum α1-AT, COX-2, and CA153

目的:探讨乳腺浸润性导管癌的超声特征及与血清α1-抗胰蛋白酶(α1-AT)、环氧合酶-2(COX-2)、癌抗原153(CA153)的相关性。方法:选取2020年7月~2023年8月浦城县妇幼保健院接诊的41例乳腺浸润性导管癌患者为观察组,另选同期接诊的良性乳腺肿块患者41例为对照组,比较两组超声图像及血清α1-AT、COX-2、CA153水平,采用Spearman相关性分析对观察组超声图像特征与血清α1-AT、COX-2、CA153的相关性进行分析。结果:观察组病灶长径/横径比、后方回声、血流分级、钙化情况与对照组比较,差异有统计学意义(P<0.05);观察组血清α1-AT、COX-2、CA153水平与对照组比较,明显更高,差异有统计学意义(P<0.05);观察组患者超声特征中的长径/横径比≥1、微小钙化、丰富血流信号与血清α1-AT、COX-2、CA153水平呈正相关性(P<0.05);结论:乳腺浸润性导管癌具有纵向生长、后方回声衰减、血流丰富、内部钙化等超声特征,患者血清α1-AT、COX-2、CA153呈异常高表达,超声部分特征与血清α1-AT、COX-2、CA153间有相关性。

Objective:To investigate the characteristics of ultrasound in invasive ductal carcinoma of the breast and its correlation with serumα1-antitrypsin(α1-AT),cyclooxygenase-2(COX-2)and cancer antigen 153(CA153).Methods:A total of 41 patients with invasive ductal carcinoma of the breast admitted to Pucheng County Maternal and Child Health Hospital from July 2020 to August 2023 were selected as the observation group,and 41 patients with benign breast masses were selected as the control group,and the ultrasound images and serumα1-AT,COX-2 and CA153 levels were compared between the two groups,and the correlation between the characteristics of ultrasound images and serumα1-AT,COX-2 and CA153 in the observation group was analyzed by Spearman correlation analysis.Results:Compared with the control group,there were statistically significant differences in the long-diameter/transversediameter ratio,posterior echo,blood flow grade and calcification of lesions in the observation group(P<0.05),the serum levels ofα1-AT,COX-2 and CA153 in the observation group were significantly higher than those in the control group(P<0.05),and the long-diameter/transverse diameter ratio in the ultrasound characteristics of the observation group was≥1,microcalcification,abundant blood flow signal and serumα1-AT,COX-2,There was a positive correlation between the level of CA153(P<0.05).Conclusion:Breast invasive ductal carcinoma has the characteristics of ultrasound,such as longitudinal growth,posterior echo attenuation,abundant blood flow,and internal calcification,and the serumα1-AT,COX-2 and CA153 were abnormally high expression,and some characteristics of ultrasound were correlated with serumα1-AT,COX-2 and CA153.