伴有外周血嗜酸粒细胞升高的慢性阻塞性肺疾病急性加重患者的临床特征分析

Clinical Characteristics of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Accompanied by Increased Peripheral Blood Eosinophils

目的探究慢性阻塞性肺疾病急性加重患者合并外周血嗜酸粒细胞(EOS)升高的临床特征情况。方法对洛阳市中心医院2019年1月至2023年11月收治的62例慢性阻塞性肺疾病急性加重期患者的一般资料情况进行回顾性分析,根据是否合并EOS升高情况分为EOS正常组(30例,EOS<100个/μL)与EOS升高组(32例,EOS≥100个/μL),比较两组患者临床特征情况和三联治疗效果。结果两组一般资料差异无统计学意义(P>0.05)。EOS升高组患者慢性阻塞性肺疾病评估测试(CAT)评分、改良英国医学研究委员会呼吸困难量表(mMRC)评分均高于EOS正常组,肺功能指标与6 min行走距离均低于EOS正常组,差异均有统计学意义(P<0.05)。EOS升高组患者接受三联治疗有效率高于EOS正常组患者,差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性加重患者合并EOS升高疾病程度更为严重,三联治疗效果较优。

Objective To explore the clinical characteristics of patients with acute exacerbation of chronic obstructive pulmonary disease accompanied by increased peripheral blood eosinophils(EOS).Methods A retrospective analysis was conducted on the general data of 62 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to Luoyang Central Hospital from January 2019 to November 2023.Based on whether EOS was elevated,patients were divided into the EOS normal group(30 cases,EOS<100 cells/μL)and the EOS elevated group(32 cases,EOS≥100 cells/μL).The clinical characteristics and the effectiveness of triple therapy were compared between the two groups.Results There were no statistically significant differences in general data between the two groups(P>0.05).The EOS elevated group had higher chronic obstructive pulmonary disease Assessment Test(CAT)scores and modified British Medical Research Council(mMRC)dyspnea scale scores,and lower lung function indicators and 6-minute walking distance compared to the EOS normal group,with statistically significant differences(P<0.05).The effectiveness rate of triple therapy was higher in the EOS elevated group than in the EOS normal group,with statistically significant differences(P<0.05).Conclusion Patients with acute exacerbation of chronic obstructive pulmonary disease accompanied by elevated EOS have a more severe disease condition and respond better to triple therapy.