地夸磷索钠与玻璃酸钠治疗屈光术后睑板腺功能障碍性干眼的临床疗效比较

Comparison of the Clinical Efficacy of Diquafosol Sodium and Sodium Hyaluronate in the Treatment of Post-Refractive Surgery Meibomian Gland Dysfunction Dry Eye

目的探究屈光术后睑板腺功能障碍性干眼患者进行地夸磷索钠与玻璃酸钠治疗的临床疗效。方法按照随机数字表法将2023年2月至2024年3月驻马店市中心医院眼科收治的120例屈光术后睑板腺功能障碍性干眼患者分为对照组(60例)、观察组(60例),研究类型为前瞻性。对照组进行玻璃酸钠治疗,观察组进行地夸磷索钠联合玻璃酸钠治疗,治疗时间为3个月,对比对照组、观察组患者治疗效果,治疗前及治疗后2个月、治疗后3个月视觉质量[调制传递函数截止频率(MTF cutoff)、患眼泪膜客观散射指数(TF-OSI)],治疗前、治疗后2个月、治疗后3个月及治疗后1周泪膜破裂时间,治疗前后泪液中因子[白细胞介素-6(IL-6)、转化生长因子-β1(TGF-β1)、细胞间粘附因子-1(ICAM-1)]水平。结果观察组治疗有效率(96.67%)高于对照组(85.00%),差异有统计学意义(P<0.05)。两组治疗后2个月、治疗后3个月MTF cutoff水平均高于治疗前,且同时段观察组MTF cutoff水平均高于对照组,差异有统计学意义(P<0.05);两组治疗后2个月、治疗后3个月TF-OSI水平均低于治疗前,且同时段观察组TF-OSI水平均低于对照组,差异有统计学意义(P<0.05)。两组治疗后2个月、治疗后3个月及治疗后1周泪膜破裂时间均长于治疗前,且同时段观察组泪膜破裂时间均长于对照组,差异有统计学意义(P<0.05)。两组治疗后IL-6、ICAM-1水平均低于治疗前,且观察组IL-6、ICAM-1水平均低于对照组,差异有统计学意义(P<0.05);两组治疗后TGF-β1水平高于治疗前,且观察组TGF-β1水平高于对照组,差异有统计学意义(P<0.05)。结论屈光术后睑板腺功能障碍性干眼患者进行地夸磷索钠与玻璃酸钠联合治疗可进一步提升疗效、视觉质量,延长泪膜破裂时间,抑制炎症反应。

Objective To explore the clinical efficacy of Diquafosol Sodium and Sodium Hyaluronate in treating patients with post-refractive surgery Meibomian Gland Dysfunction(MGD)dry eye.Methods From February 2023 to March 2024,120 patients with MGD dry eye post-refractive surgery at Zhumadian Central Hospital were randomly divided into a control group(60 cases)treated with Sodium Hyaluronate and an observation group(60 cases)treated with Diquafosol Sodium combined with Sodium Hyaluronate for three months.Efficacy was compared between the two groups,with measures including Modulation Transfer Function(MTF cutoff)frequency and Tear Film Objective Scatter Index(TF-OSI)before treatment,and after two and three months.Tear film break-up time,and levels of Interleukin-6(IL-6),Transforming Growth Factor-β1(TGF-β1),and Intercellular Adhesion Molecule-1(ICAM-1)were also compared.Results The observation group showed a higher effective rate(96.67%)compared to the control group(85.00%)with statistically significant differences(P<0.05).MTF cutoff frequency was higher and TF-OSI lower in the observation group compared to the control group at both two and three months(P<0.05).Tear film break-up time was longer,and levels of IL-6 and ICAM-1 were lower in the observation group post-treatment compared to the control group(P<0.05).TGF-β1 levels were higher in the observation group post-treatment compared to the control group(P<0.05).Conclusion Diquafosol Sodium combined with Sodium Hyaluronate further enhances efficacy,visual quality,extends tear film break-up time,and suppresses inflammatory responses in patients with post-refractive surgery MGD dry eye.