药物治疗干眼的临床应用及研究进展

Clinical application and research progress on drugs for treating dry eyes

干眼又称作干燥性角结膜炎,其临床表现为眼部干涩,有搔痒感、灼烧感、视物模糊等症状,严重影响患者的生活质量。近年来干眼的发病率逐年升高,已成为眼科临床的常见疾病之一。目前治疗干眼的手段主要有药物治疗、手术治疗和临床护理等,其中药物治疗是治疗干眼最为常用的手段。本文对近年来临床上基于渗透通路和炎症通路的药物治疗干眼的应用及研究进展进行归纳总结,为后续干眼的治疗及药物研发提供一些思路。

Dry eye,also known as keratoconjunctivitis sicca,is clinically manifested as dry eyes,itching,burning,blurred vision and other symptoms,which seriously affects the life quality of patients.In recent years,the incidence of dry eye has increased year by year,and it has become one of the common clinical diseases in ophthalmology.At present,the treatment methods of dry eye mainly include drug treatment,surgical treatment and clinical nursing,among which drug is the most commonly used method for the treatment of dry eye.Therefore,this paper summarizes the application and research progress of clinical medication of dry eye based on permeation pathways and inflammatory pathways in recent years,so as to provide some ideas for the follow-up treatment of dry eye and drug development.