酚妥拉明联合常规药物治疗肺炎支原体肺炎合并心力衰竭患儿的效果

Effects of Phentolamine combined with conventional drugs in treatment of children with mycoplasma pneumoniae pneumonia complicated with heart failure

目的:观察酚妥拉明联合常规药物治疗肺炎支原体肺炎合并心力衰竭患儿的效果。方法:选取2020年5月至2022年1月该院收治的80例肺炎支原体肺炎合并心力衰竭患儿进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各40例。对照组采用常规药物(注射用阿奇霉素、去乙酰毛花苷注射液、呋塞米)治疗,研究组在对照组基础上联合甲磺酸酚妥拉明治疗,比较两组治疗总有效率、血清炎性因子[白细胞介素(IL)-6、IL-17、IL-18]水平、血清心肌酶[乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CKMB)]水平和不良反应发生率。结果:研究组治疗总有效率为95.00%,明显高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后,两组血清IL-6、IL-17、IL-18等炎性因子水平和LDH、CK、CK-MB等心肌酶水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:酚妥拉明联合常规药物治疗肺炎支原体肺炎合并心力衰竭患儿可提高治疗总有效率,降低炎性因子和心肌酶水平,效果优于单纯常规药物治疗。

Objective:To observe effects of Phentolamine combined with conventional drugs in treatment of children with mycoplasma pneumoniae pneumonia complicated with heart failure.Methods:A prospective study was conducted on 80 children with mycoplasma pneumoniae pneumonia complicated with heart failure admitted to the hospital from May 2020 to January 2022.According to the random number table method,they were divided into study group and control group,40 cases in each group.The control group was treated with conventional drugs(Azithromycin for injection,Deslanoside injection,Furosemide),while the study group was treated with Phentolamine mesylate on the basis of that of the control group.The total effective rate,the serum inflammatory factors[interleukin(IL)-6,IL-17,IL-18]levels,the serum myocardial enzymes[lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.00%,which was significantly higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of inflammatory factors such as IL-6,IL-17,IL-18 and myocardial enzymes such as LDH,CK and CK-MB in the two groups were lower than those before treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Phentolamine combined with conventional drugs in the treatment of the children with mycoplasma pneumoniae pneumonia complicated with heart failure can improve the total effective rate of treatment,and reduce the levels of inflammatory factors and myocardial enzymes.Moreover,it is superior to simple conventional drug treatment.