阿卡波糖联合甘精胰岛素治疗老年2型糖尿病患者的效果

Effects of Acarbose combined with Insulin glargine in treatment of elderly patients with type 2 diabetes

目的:观察阿卡波糖联合甘精胰岛素治疗老年2型糖尿病患者的效果。方法:回顾性分析2021年5月至2023年2月该院收治的96例老年2型糖尿病患者的临床资料,按照治疗方法不同将其分为对照组和观察组各48例。两组均予以常规治疗,在此基础上,对照组予以甘精胰岛素治疗,观察组在对照组基础上联合阿卡波糖治疗,两组均连续治疗2个月。比较两组临床疗效,治疗前后糖脂代谢指标[空腹血糖(FPG)、餐后2 h血糖(2hPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)]、胰岛功能指标[胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)]、氧化应激指标[超氧化物歧化酶(SOD)、活性氧(ROS)、丙二醛(MDA)]水平,以及不良反应发生率。结果:观察组治疗总有效率为91.67%(44/48),高于对照组的75.00%(36/48),差异有统计学意义(P<0.05);治疗后,观察组FPG、2hPG、TG、TC、LDL-C水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组HOMA-IR水平低于对照组,HOMA-β水平高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组SOD水平高于对照组,ROS、MDA水平低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:阿卡波糖联合甘精胰岛素治疗老年2型糖尿病患者可提高治疗总有效率,降低糖脂代谢指标水平,改善胰岛功能指标、氧化应激指标水平,效果优于单纯甘精胰岛素治疗。

Objective:To observe effects of Acarbose combined with Insulin glargine in treatment of elderly patients with type 2 diabetes.Methods:The clinical data of 96 elderly patients with type 2 diabetes admitted to this hospital from May 2021 to February 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,48 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Insulin glargine,while the observation group was treated with Acarbose on the basis of that of the control group.Both groups were treated continuously for 2 months.The clinical efficacy,the levels of glucose and lipid metabolism indexes[fasting blood glucose(FPG),2 h postprandial blood glucose(2hPG),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)],islet function indexes[insulin resistance index(HOMA-IR),isletβcell function index(HOMA-β)]and oxidative stress indexes[superoxide dismutase(SOD),reactive oxygen species(ROS),malondialdehyde(MDA)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.67%(44/48),which was higher than 75.00%(36/48)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of FPG,2hPG,TG,TC and LDL-C in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the HOMA-IR level in the observation group was lower than that in the control group,the HOMA-βlevel was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of SOD in the observation group was higher than that in the control group,the levels of ROS and MDA were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Acarbose combined with Insulin glargine in the treatment of the elderly patients with type 2 diabetes can improve the total effective rate of treatment,reduce the levels of glucose and lipid metabolism indexes,improve the levels of islet function indexes and oxidative stress indexes.Moreover,it is superior to simple Insulin glargine treatment.