摘要
目的:观察醋酸戈舍瑞林联合腹腔镜子宫肌瘤剔除术治疗子宫肌瘤患者的效果。方法:回顾性分析2020年11月至2023年11月该院收治的80例子宫肌瘤患者的临床资料,依据手术方法不同将其分为观察组(n=40)和对照组(n=40)。对照组采用腹腔镜子宫肌瘤剔除术治疗,观察组采用醋酸戈舍瑞林联合腹腔镜子宫肌瘤剔除术治疗,比较两组治疗前后性激素指标[雌二醇(E_(2))、卵泡刺激素(FSH)、促黄体生成素(LH)]、生化指标[表皮生长因子(EGF)、转化生长因子-β1(TGF-β1)、血管内皮生长因子(VEGF)]水平,术后1周并发症发生率,以及复发率。结果:治疗后,观察组E_(2)、FSH、LH水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组EGF、TGF-β1、VEGF水平均低于对照组,差异有统计学意义(P<0.05);两组并发症发生率比较,差异无统计学意义(P>0.05);两组术后3个月总复发率比较,差异无统计学意义(P>0.05)。结论:醋酸戈舍瑞林联合腹腔镜子宫肌瘤剔除术治疗子宫肌瘤患者可降低性激素指标和生化指标水平,效果优于单纯腹腔镜子宫肌瘤剔除术治疗。
Objective:To observe effects of Goserelin acetate combined with laparoscopic hysteromyomectomy in treatment of patients with uterine fibroids.Methods:The clinical data of 80 patients with uterine fibroids admitted to this hospital from November 2020 to November 2023 were retrospectively analyzed.According to different surgical methods,they were divided into observation group(n=40)and control group(n=40).The control group was treated with laparoscopic hysteromyomectomy,while the observation group was treated with Goserelin acetate combined with laparoscopic hysteromyomectomy.The levels of sex hormone indexes[estradiol(E_(2)),follicle stimulating hormone(FSH),luteinizing hormone(LH)]and biochemical indexes[epidermal growth factor(EGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)]before and after the treatment,the incidence of complications,and the recurrence rate 1 week after the surgery were compared between the two groups.Results:After the treatment,the levels of E_(2),FSH and LH in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of EGF,TGF-β1 and VEGF in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the two groups(P>0.05).There was no significant difference in the total recurrence rate between the two groups 3 months after the surgery(P>0.05).Conclusions:Goserelin acetate combined with laparoscopic hysteromyomectomy can reduce the levels of sex hormone indexes and biochemical indexes in the patients with uterine fibroids.Moreover,it is superior to simple laparoscopic hysteromyomectomy.
作者
徐晓燕
XU Xiaoyan(Department of Obstetrics and Gynecology of Nanle Zhongxing Hospital,Puyang 457400 Henan,China)
出处
《中国民康医学》
2024年第21期71-73,共3页
Medical Journal of Chinese People’s Health
关键词
醋酸戈舍瑞林
腹腔镜子宫肌瘤剔除术
子宫肌瘤
性激素
生化指标
复发率
并发症
Goserelin acetate
Laparoscopic hysteromyomectomy
Uterine fibroids
Sex hormone
Biochemical index
Recurrence rate
Complication