重复经颅磁刺激联合听觉统合训练在孤独症患儿中的应用效果

Application effects of repetitive transcranial magnetic stimulation combined with auditory integration training in children with autism

目的:探讨重复经颅磁刺激(rTMS)联合听觉统合训练(AIT)在孤独症患儿中的应用效果。方法:选取2020年4月至2023年3月郑州大学附属儿童医院收治的100例孤独症患儿进行前瞻性研究,以随机数字表法将其分为对照组和观察组各50例。两组均接受常规治疗,在此基础上,对照组予以AIT治疗,观察组在对照组基础上联合rTMS治疗,比较两组临床疗效、治疗前后孤独症状[孤独症儿童行为量表(ABC)]评分和感觉统合失调(感觉统合评定量表)评分。结果:观察组治疗总有效率为94.00%(47/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05);治疗后,观察组生活自理、交往能力、感觉能力、语言能力、运动能力等ABC评分及总分均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组前庭失衡、触觉防御、本体感觉、学习能力、特殊问题等感觉统合评定量表评分及总分均高于对照组,差异有统计学意义(P<0.05)。结论:rTMS联合AIT应用于孤独症患儿可提高治疗总有效率和感觉统合失调评分,降低孤独症状评分,效果优于单纯AIT。

Objective:To explore application effects of repetitive transcranial magnetic stimulation(rTMS)combined with auditory integration training(AIT)in children with autism.Methods:A prospective study was conducted on 100 children with autism who were admitted to the Children’s Hospital Affiliated to Zhengzhou University from April 2020 to March 2023.They were divided into control group and observation group by using the random number table method,50 cases in each group.Both groups received conventional treatment.On this basis,the control group was treated with AIT,while the observation group was treated with rTMS on the basis of that of the control group.The clinical efficacy and the scores of autism symptoms[autism behavior checklist(ABC)]and sensory integration dysfunction(sensory integration rating scale)were compared between the two groups before and after the treatment.Results:The total effective rate of the observation group was 94.00%(47/50),which was higher than 80.00%(40/50)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the ABC scores of self-care ability,communication ability,sensory ability,language ability and exercise ability and the total score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,after the treatment,the scores of sensory integration rating scale including vestibular imbalance,tactile defense,proprioception,learning ability,special problems and the total score in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:The application of rTMS combined with AIT in children with autism can improve the total effective rate of treatment and sensory integration disorder score,and reduce the loneliness symptom score.The effect is better than simple AIT.