苏黄止咳胶囊联合布地奈德福莫特罗吸入治疗支气管哮喘急性期患者的效果

Effects of Suhuang Zhike capsules combined with Budesonide and Formoterol inhalation in treatment of acute bronchial asthma

目的:观察苏黄止咳胶囊联合布地奈德福莫特罗吸入治疗支气管哮喘急性期患者的效果。方法:选取2022年3月至2023年9月该院收治的62例支气管哮喘急性期患者进行前瞻性研究,根据随机数字表法将其分为研究组与对照组各31例。对照组给予布地奈德福莫特罗吸入治疗,研究组在对照组基础上联合苏黄止咳胶囊治疗。比较两组临床疗效,治疗前后气道阻力指标[总气道阻力(R5)、呼吸道总阻抗(Z5)、中心气道阻力(R20)]、炎性因子[白细胞介素-33(IL-33)、肿瘤坏死因子-α(TNF-α)、嗜酸性粒细胞计数(EOS)]水平,以及不良反应发生率。结果:研究组治疗总有效率为93.55%(29/31),高于对照组的74.19%(23/31),差异有统计学意义(P<0.05);治疗后,两组R5、Z5、R20水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组IL-33、TNF-α、EOS水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:苏黄止咳胶囊联合布地奈德福莫特罗吸入治疗支气管哮喘急性期患者可提高治疗总有效率,以及降低气道阻力指标和炎性因子水平的效果优于单纯布地奈德福莫特罗吸入治疗。

Objective:To observe effects of Suhuang Zhike capsules combined with Budesonide and Formoterol inhalation in treatment of patients with acute bronchial asthma.Methods:A prospective study was conducted on 62 patients with acute bronchial asthma admitted to the hospital from March 2022 to September 2023.According to the random number table method,they were divided into study group and control group,31 cases in each group.The control group was treated with Budesonide and Formoterol inhalation,while the study group was treated with Suhuang Zhike capsules on the basis of that of the control group.The clinical efficacy,the levels of airway resistance indexes[total airway resistance(R5),total airway resistance(Z5),central airway resistance(R20)]and inflammatory factors[interleukin-33(IL-33),tumor necrosis factor-α(TNF-α),eosinophil count(EOS)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 93.55%(29/31),which was higher than 74.19%(23/31)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of R5,Z5 and R20 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of IL-33,TNF-αand EOS in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Suhuang Zhike capsules combined with Budesonide and Formoterol inhalation in the treatment of the patients with acute bronchial asthma can improve the total effective rate of treatment and reduce the levels of airway resistance indexes and inflammatory factors.Moreover,it is superior to simple of Budesonide and Formoterol inhalation treatment.