玉屏风颗粒联合氯雷他定片治疗慢性荨麻疹患者的效果

Effects of Yupingfeng granules combined with Loratadine tablets in treatment of chronic urticaria patients

目的:观察玉屏风颗粒联合氯雷他定片治疗慢性荨麻疹患者的效果。方法:选取2021年1月至2023年12月该院收治的60例慢性荨麻疹患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各30例。对照组采用氯雷他定片口服治疗,观察组在对照组基础上联合玉屏风颗粒治疗。比较两组临床疗效,治疗前后风团情况、中医证候积分,以及不良反应发生率。结果:观察组治疗总有效率为93.33%(28/30),高于对照组的73.33%(22/30),差异有统计学意义(P<0.05);治疗后,两组风团数量、发作频率均少于治疗前,且观察组少于对照组,两组发作持续时间均短于治疗前,且观察组短于对照组,差异有统计学意义(P<0.05);两组风团反复发作、遇冷或风吹加剧、瘙痒、汗出恶风等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:玉屏风颗粒联合氯雷他定片治疗慢性荨麻疹患者可提高治疗总有效率,改善风团情况,降低中医证候积分的效果优于单纯氯雷他定片治疗。

Objective:To observe effects of Yupingfeng granules combined with Loratadine tablets in treatment of patients with chronic urticaria.Methods:A prospective study was conducted on 60 patients with chronic urticaria admitted to this hospital from January 2021 to December 2023.According to the random number table method,they were divided into control group and observation group,30 cases in each group.The control group was treated with Loratadine tablets orally,while the observation group was treated with Yupingfeng granules on the basis of that of the control group.The clinical efficacy,the wheal situation,the traditional Chinese medical(TCM)syndrome score before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 93.33%(28/30),which was higher than 73.33%(22/30)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the number and frequency of wheals in the two groups were less than those before the treatment,and those in the observation group were less than those in the control group;the duration of wheals in the two groups were shorter than those before the treatment,and that in the observation group was shorter than that in the control group;and the differences were statistically significant(P<0.05).The scores of TCM syndromes such as recurrent attack of wheal,aggravation when it is cold or winding,itching,evil wind when sweating in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Yupingfeng granules combined with Loratadine tablets in the treatment of the patients with chronic urticaria can improve the total effective rate of treatment,improve the wheal situation,and reduce the TCM syndrome scores.Moreover,it is superior to simple Loratadine tablets treatment.