黄芪对气虚证2型糖尿病患者的临床疗效

Clinical effects of Astragali Radix on patients with type 2 diabetes mellitus of Qi Deficiency Pattern

目的探讨黄芪对气虚证2型糖尿病患者的临床疗效。方法90例患者随机分为对照组和观察组,每组45例,2组均采用常规治疗,同时对照组给予原治疗方案,观察组在对照组基础上加用黄芪颗粒,疗程12周。检测中医证候疗效和评分、血管内皮功能指标及炎症因子(FMD、NO、ET-1、MHR、CRP)、糖代谢指标(FBG、2 hPBG、HbA1C、FCP)、脂代谢指标(TC、TG、HDL-C、LDL-C)、安全性指标变化。结果观察组中医证候总有效率高于对照组(P<0.05)。治疗后,观察组FMD、NO高于对照组(P<0.05),MHR、2 hPBG、HbA1C、TC、TG及气短、神疲、乏力评分更低(P<0.05)。2组未发现明显不良反应。结论黄芪可安全有效地改善气虚证2型糖尿病患者血管内皮功能障碍,值得临床推广。

AIM To explore the clinical effects of Astragali Radix on patients with type 2 diabetes mellitus of Qi Deficiency Pattern.METHODS Ninety patients were randomly assigned into control group(45 cases)for 12-week intervention of both conventional treatment and original treatment regimen,and observation group(45 cases)for 12-week intervention of conventional treatment,original treatment regimen and Astragali Radix granules.The changes in TCM syndrome effects and scores,vascular endothelial function indices and inflammatory cytokines(FMD,NO,ET-1,MHR,CRP),glucose metabolism indices(FBG,2 hPBG,HbA1C,FCP),lipid metabolism indices(TC,TG,HDL-C,LDL-C)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate of TCM syndromes than the control group(P<0.05).After the treatment,the observation group displayed higher FMD and NO than the control group(P<0.05),along with lower MHR,2 hPBG,HbA1C,TC,TG and scores for shortness of breath,fatigue,weakness(P<0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with type 2 diabetes mellitus of Qi Deficiency Pattern,Astragali Radix can safely and effectively improve vascular endothelial dysfunction,which is worthy of clinical popularization.