摘要
A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research.Its salient features include high yield,excellent chemo-and enantioselectivity,mild conditions,a broad substrate scope as well as versatile transformations of the product.
基金
support of the National Key R&D Program of China(No.2021YFF0701600),NSFC(No.22031004)
the Shanghai Municipal Education Commission(No.20212308)
China Postdoctoral Science Foundation(No.2022M713667)and STCSM(No.23ZR1445600).
