猪丁型冠状病毒拮抗细胞焦亡的研究进展

Antagonism of pyroptosis by porcine deltacoronavirus

猪丁型冠状病毒(porcine deltacoronavirus, PDCoV)是一种新发现的猪肠道致病性病毒,呈现全球流行趋势,能够引起仔猪腹泻、呕吐、脱水,给养猪业带来重大的经济损失。该病毒具有跨种传播特征,能够感染人类和养殖动物,对动物和人类的健康存在一定的威胁。细胞焦亡是由Gasdermin家族蛋白介导的细胞程序性死亡,在病原感染过程中发挥防御和清除的作用。冠状病毒在长期的进化过程中形成了拮抗焦亡逃逸宿主天然免疫反应的策略。本文对PDCoV的主要生物学特征、细胞焦亡的过程以及PDCoV对Gasdermin D介导的细胞焦亡的拮抗作用进行综述,为深入了解PDCoV拮抗宿主免疫反应的机制以及防控PDCoV的感染提供一定的理论支撑。

Porcine deltacoronavirus(PDCoV),an emerging virus globally prevalent,causes watery diarrhea,vomiting,and dehydration of newborn piglets,posing severe economic losses in the swine industry.Moreover,with the characteristic of cross-species transmission,PDCoV can infect human*actamicro@im.ac.cn,'010-64807516 and farmed animals,posing a serious threat to human health.Pyroptosis is a form of programmed cell death mediated by members of the Gasdermin family,which plays a role in defending and eliminating viruses.Coronaviruses,however,have developed precise strategies to antagonize pyroptosis and evade immune responses.This review expounds the biological characteristics of PDCoV,the process of pyroptosis,and the antagonism of Gasdermin D-mediated pyroptosis by PDCoV,aiming to enrich the knowledge about the antagonism of immune responses by PDCoV and lay a theoretical foundation for the prevention and control of this virus.