肺移植患者术后血清cTnI变化的单中心回顾性研究

Changes of serum cTnI level in patients after lung transplantation:A retrospective study in a single center

目的探讨肺移植患者术后血清心脏特异性肌钙蛋白I(cardiac-specific troponin I,cTnI)的变化情况。方法回顾性分析武汉大学人民医院2016年12月—2022年12月实施肺移植患者的临床资料。探讨术后血清cTnI和临床特征间的关系。结果纳入20例患者,其中男15例、女5例,平均年龄(51.65±12.79)岁。肺移植术后血清cTnI显著升高,术后第1天到达最高值,术后第3天起出现显著下降。术后当天和术后第1天阻塞性肺病患者血清cTnI显著高于限制性肺病患者(P<0.05),双肺移植患者高于单肺移植患者(P<0.05)。结论肺移植术后可出现一过性心肌损伤,表现为血清c TnI的异常升高。

Objective To investigate the changes of serum cardiac-specific troponin I(cTnI)level in patients after lung transplantation.Methods Clinical data of patients undergoing lung transplantation in our hospital from December 2016 to December 2022 were retrospectively analyzed.The relationship between postoperative serum cTnI level and clinical characteristics were explored.Results Finally 20 patients were collected,including 15 males and 5 females with an average age of(51.65±12.79)years.The serum cTnI level was significantly increased after lung transplantation.The serum cTnI reached the highest level on the first day after transplantation,and significantly decreased from the third day after transplantation.The serum cTnI levels in patients with obstructive pulmonary disease and bilateral lung transplantation were significantly higher than those in patients with restrictive pulmonary disease and unilateral lung transplantation on the day after surgery and on the first day after transplantation.Conclusion Transient myocardial injury can occur after lung transplantation,which is characterized by an abnormal increase in serum cTnI level.