摘要
The antitumor immune response plays a crucial role in successful cancer treatment.In a recent article in Science,Giampazolias et al.[1]reported a vitamin D(VitD)-mediated antitumor mechanism in murine intestinal epithelial cells(IECs)associated with a specific microbiota signature(Bacteroides fragilis)that enhances the antitumor immune response.The strong positive association between VitD-dependent microbiota and the antitumor immune response provides a proof-of-concept for supplementing immunotherapy regimens with VitD to strengthen antitumor immunity and improve immunotherapysuccess.
基金
supported by the Ministry of Science and Innovation and the Spanish Research Agency through FEDER funds(PID2021-1261520B-100)(MICINN/AEI/FEDER,EU).
