运动干预非酒精性脂肪性肝病进程的研究进展

Research progress of exercise improve non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是常见的慢性肝脏疾病,表现为肝细胞内脂肪的异常堆积。其主要病因包括肥胖、糖尿病、高脂血症等代谢性疾病。近年来,NAFLD等代谢性疾病已成为全球性的公共卫生问题。NAFLD的药物治疗虽然已取得一定进步,但疗效有限且不良反应较多。运动疗法作为一种安全性高、不良反应少的治疗手段,在NAFLD等代谢性疾病的治疗中具有良好的应用前景;但如何克服患者运动依从性低的问题,寻求安全有效的相关药物靶点,仍面临挑战。本文探讨运动疗法在NAFLD等代谢性疾病治疗中的作用机制与应用前景,概述运动引起的能量消耗、代谢途径和组织器官间交流变化,以期为临床防治提供有益参考。

Non-alcoholic fatty liver disease(NAFLD)is a common chronic liver disease characterized by excess fat accumulation within liver cells.The main causes include obesity,diabetes,and hyperlipidemia.In recent years,NAFLD and other metabolic diseases have become global public health issues.Although some progress has been made in the drug treatment of NAFLD,the efficacy is limited and there are many adverse effects.As a treatment method with high safety and few adverse effects,exercise therapy has good application prospects in the treatment of NAFLD and other metabolic diseases.However,challenges remain in overcoming patients'low exercise compliance and in finding safe and effective exercise therapy drug targets.This article explores the mechanisms and application prospects of exercise therapy in the treatment of NAFLD and other metabolic diseases,summarizes the energy consumption,metabolic pathways,and inter-organ communication induced by exercise,aiming to provide useful references for clinical practitioners.