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Roles of Setbp1 in developmental hematopoiesis and acute myeloid leukemia

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摘要 Gain-of-function somatic mutations of SET binding protein 1(SETBP1)result in the accumulation of SETBP protein and are detected in 17%of secondary acute myeloid leukemia(AML)patients.1 In fact,high expression of SETBP1 also drives adverse outcomes in human AML.However,the roles of SETBP1 during developmental hematopoiesis and AML progression are still not fully understood.Here we first sought to investigate the functions of SETBP1 in developmental hematopoiesis.
出处 《Genes & Diseases》 SCIE CSCD 2024年第6期16-19,共4页 基因与疾病(英文)
基金 supported by grants from the National Natural Science Foundation of China (No.32000569) the Basic and Applied Basic Research Foundation of Guangdong Province,China (No.2019A1515110281).
关键词 ACUTE MYELOID LEUKEMIA
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