基于数据挖掘的国家专利中药复方治疗良性前列腺增生用药规律研究

Study on Medication Law of National Patented Chinese Herbal Prescriptions for the Treatment of Benign Prostatic Hyperplasia Based on Data Mining

目的挖掘中医药治疗良性前列腺增生国家专利组方规律,为临床用药提供参考。方法检索国家知识产权局专利检索及分析系统2000年1月1日-2023年10月31日收录的中药复方治疗良性前列腺增生专利数据,运用Excel2016、SPSS Modeler 18.0、SPSS Statistics 27、Cytoscape3.10.0软件对专利涉及中药的频次、功效类别、性味归经、核心复杂共现网络和潜在中药集群进行分析。结果纳入专利182项,涉及中药404味,总频次为2054,其中频次≥20的中药22味,高频药物有黄芪、甘草、黄柏、淫羊藿、丹参、车前子、茯苓、王不留行、泽泻和赤芍等;高频药物以补虚药(267次,13.00%)、活血化瘀药(216次,10.52%)、利水渗湿药(147次,7.16%)为主;性味以甘味、寒性为主,多归肝经、肾经;关联规则分析共得到10条,常见药对包括山萸肉-熟地黄、莪术-三棱、黄芪-党参;置信度较高的角药为当归-黄柏-甘草;聚类分析得到5个药物组合;潜在中药集群分析得到5组,其中“干姜-龙骨-独活-葱须-谷糠-透骨草”网络药物互联度最高(Score=6)。结论中药复方治疗良性前列腺增生国家专利遣方用药以补益脾肾、活血化瘀、清热利湿为主,可为临床用药提供参考。

Objective To explore the prescribing law of TCM in national patents for the treatment of benign prostatic hyperplasia(BPH);To provide a reference for clinical medication.Methods Data on TCM compound prescriptions for the treatment of BPH were retrieved from the China National Intellectual Property Administration(CNIPA)patent retrieval and analysis system,covering the period from January 1,2000,to October 31,2023.The frequency,efficacy category,properties and tastes,meridian tropism,core complex co-occurrence network,and potential TCM clusters mentioned in the patents were analyzed using Excel 2016,SPSS Modeler 18.0,SPSS Statistics 27,and Cytoscape 3.10.0 software.Results A total of 182 patents were included,involving 404 kinds of Chinese materia medica,with a total frequency of 2054 times.Among them,22 kinds of Chinese materia medica had a frequency of≥20,with the most frequently used Chinese materia medica being Astragali Radix,Glycyrrhizae Radix et Rhizoma,Phellodendri Chinensis Cortex,Epimedii Folium,Salviea Miltiorrhizae Radix et Rhizoma,Plantaginis Semen,Poria,Vaccariae Semen,Alismatis Rhizoma and Paeoniae Radix Rubra.The high-frequency herbs primarily consisted of tonifying herbs(267 times,13.00%),blood circulation-activating and stasis-resolving herbs(216 times,10.52%),and diuretic and dampness-percolating herbs(147 times,7.16%).The properties of the herbs were mainly sweet and cold,and they were mainly attributed to the liver and kidney meridians.Association rule analysis yielded 10 common drug pairs,including Cornus Officinalis-Rehmannize Radix et Praeparata,Curcumae Rhizoma-Sparganii Rhizoma,and Astragali Radix-Codonopsis Radix.The drug combination with the highest confidence was Angelicae Sinensis Radix-Phellodendri Chinensis Cortex-Glycyrrhizae Radix et Rhizoma.Clustering analysis revealed five drug combinations,while potential TCM clustering analysis identified five groups,among which the“Zingiberis Rhizoma Os Draconis-Angelicae Pubescentis Radix-Scallion-Rice Bran-Speranskiae Herba”network demonstrated the highest degree of interconnection(Score=6).Conclusion The high-frequency herbs in national patents for the treatment of BPH with TCM compound prescriptions mainly focus on tonifying the spleen and kidney,activating blood circulation to remove stasis,and clearing heat and draining dampness,providing a reference for clinical practice.