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头孢噻肟联合乙酰半胱氨酸治疗新生儿肺炎的疗效及对炎症因子的影响

Efficacy of Cefotaxime Combined with Acetylcysteine in the Treatment of Neonatal Pneumonia and Its Effect on Inflammatory Factors
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摘要 目的分析头孢噻肟联合乙酰半胱氨酸治疗新生儿肺炎的疗效及对炎症因子的影响。方法随机选取2020年1月—2024年1月三穗县人民医院收治的100例新生儿肺炎患儿为研究对象,根据不同治疗方法分成观察组和对照组,每组50例。对照组静脉滴注头孢噻肟钠,观察组在对照组的基础上,联合使用乙酰半胱氨酸溶液治疗,比较两组的临床疗效、症状改善时间及血清炎症因子水平。结果观察组的治疗总有效率为98.00%(49/50),高于对照组的84.00%(42/50),差异有统计学意义(χ^(2)=4.396,P=0.036)。观察组的症状改善时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患儿的C反应蛋白和降钙素原均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。结论头孢噻肟钠联合乙酰半胱氨酸,可以在短期内缓解新生儿肺炎的症状,降低炎症因子水平,提高临床疗效。 Objective To analyze the effect of cefotaxime combined with acetylcysteine in the treatment of neonatal pneumonia and its effect on inflammatory factors.Methods A total of 100 children with neonatal pneumonia admitted to Sansui County People's Hospital from January 2020 to January 2024 were randomly selected as the research ob⁃jects.According to different treatment methods,they were divided into observation group and control group,with 50 cases in each group.The control group was treated with intravenous drip of cefotaxime sodium,and the observation group was treated with acetylcysteine solution on the basis of the control group.The clinical efficacy,symptom im⁃provement time and serum inflammatory factor levels were compared between the two groups.Results The total effec⁃tive rate of treatment in the observation group was 98.00%(49/50),which was higher than 84.00%(42/50)in the con⁃trol group,and the difference was statistically significant(χ^(2)=4.396,P=0.036).The symptom improvement time of the observation group was shorter than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of C-reactive protein and procalcitonin in the two groups decreased,and those in the obser⁃vation group were lower than the control group,the differences were statistically significant(all P<0.05).Conclusion Cefotaxime sodium combined with acetylcysteine can relieve the symptoms of neonatal pneumonia in the short term,reduce the level of inflammatory factors and improve the clinical efficacy.
作者 田洋 王绍国 TIAN Yang;WANG Shaoguo(Department of Neonatology,Sansui County People's Hospital,Kaili,Guizhou,556590,China)
出处 《中外医疗》 2024年第26期86-88,96,共4页 China & Foreign Medical Treatment
关键词 头孢噻肟 乙酰半胱氨酸 新生儿肺炎 疗效 炎症因子 Cefotaxime Acetylcysteine Neonatal pneumonia Efficacy Inflammatory factors
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