摘要
Degenerated endplate appears with cheese-like morphology and sensory innervation,contributing to low back pain and subsequently inducing intervertebral disc degeneration in the aged population.1 However,the origin and development mechanism of the cheese-like morphology remain unclear.Here in this study,we report lumbar instability induced cartilage endplate remodeling is responsible for this pathological change.
基金
supported by National Natural Science Foundation of China (82172468,82372436 and 32301416)
Natural Science Foundation of Jiangsu Province (BK20211326)
Natural Science Fund for Colleges and Universities in Jiangsu Province (21KJB320009)。