Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
摘要
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.However,the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood.Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion.
基金
supported by the Bayerische Forschungsstiftung to B.K.
the Deutsche Forschungsgemeinschaft (CRC1181 to G.K.and G.S.
SCHE 2062/1-1 to C.S.)
funded by the Wellcome Trust Investigator Award (107964/Z/15/Z)
the UK Dementia Research Institute
funded by BBSRC Discovery Fellowship (BB/T009543/1)。
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