关节腔玻璃酸钠注射联合中药熏洗在膝关节炎治疗中的应用效果分析

Analysis of the application effect of articular cavity injection of sodium hyaluronate combined with traditional Chinese medicine fumigation in the treatment of knee arthritis

目的探讨关节腔玻璃酸钠注射联合中药熏洗在膝关节炎治疗中的应用效果。方法选取100例膝关节炎患者作为研究对象,将其随机分为中药联合治疗组与玻璃酸钠治疗组,各50例。玻璃酸钠治疗组给予关节腔玻璃酸钠注射,中药联合治疗组给予关节腔玻璃酸钠注射联合中药熏洗。比较两组患者临床效果、治疗前后骨关节炎严重程度评分、治疗前后血清炎性因子水平、治疗前后美国膝关节协会(AKS)评分。结果中药联合治疗组临床总有效率(94.00%)较玻璃酸钠治疗组(68.00%)明显更高,研究数据具有统计学意义(P<0.05)。治疗后,两组患者疼痛、僵硬、关节功能评分均较治疗前降低,且中药联合治疗组疼痛评分(5.27±0.59)分、僵硬评分(2.53±0.34)分、关节功能评分(22.15±2.83)分低于玻璃酸钠治疗组的(8.23±1.35)、(4.27±1.06)、(26.41±4.37)分(P<0.05)。治疗后,中药联合治疗组白细胞介素-6(IL-6)(54.26±3.64)ng/L、C反应蛋白(CRP)(3.15±0.28)mg/L、D-二聚体(D-D)(103.08±8.51)ng/ml均低于玻璃酸钠治疗组的(72.45±8.39)ng/L、(5.08±1.82)mg/L、(126.21±14.39)ng/ml(P<0.05)。治疗后,中药联合治疗组膝评分(80.57±5.03)分和功能评分(85.18±5.19)分显著高于玻璃酸钠治疗组的(70.26±5.01)、(75.45±5.07)分(P<0.05)。结论关节腔玻璃酸钠注射联合中药熏洗用于膝关节炎治疗中不仅能显著缓解疼痛和僵硬,还能够减少炎症反应,疗效显著,具有临床推广价值。

Objective To explore the application effect of articular cavity injection of sodium hyaluronate combined with traditional Chinese medicine fumigation in the treatment of knee arthritis.Methods A total of 100 patients with knee arthritis were selected as the study subjects and randomly divided into traditional Chinese medicine combined treatment group and sodium hyaluronate treatment group,with 50 cases in each group.The sodium hyaluronate treatment group was given articular cavity injection of sodium hyaluronate,and the traditional Chinese medicine combined treatment group was given articular cavity injection of sodium hyaluronate combined with traditional Chinese medicine fumigation.Patients in both groups were compared in terms of clinical effect,knee function score before and after treatment,serum inflammatory factor level before and after treatment,and American Knee Society(AKS)score before and after treatment.Results The total clinical effective rate in the traditional Chinese medicine combined treatment group(94.00%)was significantly higher than that in the sodium hyaluronate treatment group(68.00%),the study data was statistically significant(P<0.05).After treatment,the pain,stiffness and joint function scores in both groups were lower than those before treatment;in the traditional Chinese medicine combined treatment group,the pain score was(5.27±0.59)points,the stiffness score was(2.53±0.34)points and the joint function score was(22.15±2.83)points,which were lower than(8.23±1.35),(4.27±1.06)and(26.41±4.37)points in the sodium hyaluronate treatment group(P<0.05).After treatment,the traditional Chinese medicine combined treatment group had interleukin-6(IL-6)of(54.26±3.64)ng/L,C-reactive protein(CRP)of(3.15±0.28)mg/L and D-dimer(D-D)of(103.08±8.51)ng/ml,which were lower than(72.45±8.39)ng/L,(5.08±1.82)mg/L and(126.21±14.39)ng/ml in the sodium hyaluronate treatment group(P<0.05).After treatment,the traditional Chinese medicine combined treatment group had knee score of(80.57±5.03)points and functional score of(85.18±5.19)points,which were significantly higher than(70.26±5.01)and(75.45±5.07)points in the sodium hyaluronate treatment group(P<0.05).Conclusion Articular cavity injection of sodium hyaluronate combined with traditional Chinese medicine fumigation is effective in the treatment of knee arthritis,which can not only significantly relieve pain and stiffness,but also reduce inflammatory response,and has clinical promotion value.