支气管肺炎患儿抗生素治疗前后肠道菌群的变化及其临床意义

Changes of Intestinal Flora in Children with Bronchopneumonia before and after Antibiotic Treatment and its Clinical Significance

【目的】探讨支气管肺炎患儿抗生素治疗前后肠道菌群的变化及其临床意义。【方法】选取2020年10月至2022年10月本院收治的112例支气管肺炎患儿作为观察组,给予大环内酯类抗生素连续治疗14 d;另外选取同期在本院体检的60例健康儿童作为对照组。比较两组及观察组不同严重程度支气管肺炎患儿的肠道菌群情况,统计观察组不同年龄段患儿治疗后肠道菌群失调情况。【结果】观察组志贺菌、沙门菌和致病性大肠杆菌显著高于对照组(P<0.05)。观察组轻度、中度、重度患儿志贺菌、沙门菌和致病性大肠杆菌依次增高,差异均有统计学意义(P<0.05)。经抗生素治疗后,支气管肺炎患儿志贺菌、沙门菌和致病性大肠杆菌含量较治疗前均上升(P<0.05)。<3岁肠道菌群失调患儿比例高于≥3岁患儿(χ^(2)=11.479,P<0.05)。【结论】支气管肺炎患儿肠道菌群失调,抗生素治疗能进一步影响肠道菌群,<3岁患儿易发生肠道菌群失调。

【Objective】To investigate the changes and clinical significance of intestinal flora in children with bronchial pneumonia before and after antibiotic treatment.【Methods】A total of 112 children with bronchopneumonia treated in our hospital from October 2020 to October 2022 were selected as the observation group and given macrolide antibiotics for 14 days.In addition,60 healthy children who underwent physical examination in our hospital during the same period were selected as the control group.The intestinal flora of children with bronchopneumonia of different severity were compared between the two groups and the observation group.The imbalance of intestinal flora in children of different age groups after treatment was analyzed.【Results】Shigella,Salmonella and pathogenic Escherichia coli in observation group were significantly higher than those in control group(P<0.05).Shigella,salmonella and pathogenic Escherichia coli increased successively in mild,moderate and severe children in the observation group,and the differences were statistically significant(P<0.05).After treatment with antibiotics,the contents of Shigella,Salmonella and pathogenic Escherichia coli in children with bronchopneumonia were higher than those before treatment(P<0.05).The proportion of children<3 years old with intestinal flora disorder was higher than that of children≥3 years old(χ^(2)=11.479,P<0.05).【Conclusion】The intestinal flora of children with bronchopneumonia is dysregulated,and antibiotic treatment can further affect the intestinal flora.Children<3 years old are prone to intestinal flora dysregulation.