高尔基体糖蛋白73及过氧化物酶3与慢性乙肝相关性肝癌患者预后的关系

Relationship between of Golgi Protein 73 and Myeloperoxidase 3 with the Prognosis of Chronic Hepatitis B-related Hepatocellular Carcinoma Related to Chronic Hepatitis B

【目的】探讨高尔基体糖蛋白73(GP73)及过氧化物酶3(MPO3)与慢性乙肝(CHB)相关性肝癌预后的关系。【方法】以101例CHB相关性肝癌患者为观察组,90例健康志愿者为对照组。比较两组血清GP73、MPO3水平。随访2年,统计观察组患者生存情况,并据此分为死亡组(21例)和存活组(80例),比较死亡组和存活组患者的临床资料,分析影响患者预后的危险因素GP73、MPO3及两者联合检测对患者预后的预测效能。【结果】观察组GP73水平高于对照组,MPO3水平低于对照组(P<0.05)。CHB相关性肝癌患者病死率为20.79%(21/101)。死亡组患者Ⅲ~Ⅳ期占比、低分化占比、肿瘤最大直径>5 cm占比、肿瘤数目>2个占比、淋巴结转移占比、GP73均高于存活组,MPO3低于存活组(P<0.05)。Logistic回归分析显示,临床分期、GP73及MPO3均为患者预后的影响因素(P<0.05)。受试者工作特征(ROC)曲线分析显示,GP73、MPO3及两者联合检测预测患者预后的曲线下面积(AUC)分别为0.803、0.717和0.913。【结论】血清GP73、MPO3与CHB相关性肝癌患者的预后存在一定的相关性,且两者联合对患者预后的预测效能较高。

【Objective】To explore the relationship between of Golgi protein 73(GP73)and myeloperoxidase 3(MPO3)with the prognosis of hepatocellular carcinoma(HCC)related to chronic hepatitis B(CHB).【Methods】The study involved included 104 patients with CHB-related HCC as the observation group and 90 healthy volunteers as the control group.Serum levels of GP73 and MPO3 were compared between the two groups.A two-year follow-up was conducted to track the survival of the observation group.Based on survival outcomes,patients of the observation group were divided into the death group(21 cases)and the survival group(80 cases).Clinical data between the death and survival groups were compared,and risk factors affecting patient prognosis were analyzed.The predictive efficiency of GP73,MPO3,and their combined detection for patient prognosis was evaluated.【Results】The GP73 level in the observation group was higher than that in the control group,while the MPO3 level was lower(P<0.05).The mortality rate of CHB-related HCC patients was 20.79%(21/101).The death group had higher proportions of patients in stageⅢ~Ⅳ,poorly differentiated tumors,maximum tumor diameter>5 cm,multiple tumors(>2),lymph node metastasis compared to the survival group,and elevated the level of GP73 was higher levels,with and lower MPO3 levels was lower in the death group than those in the survival group(P<0.05).Logistic regression analysis showed that clinical stage,GP73,and MPO3 were factors influencing patient prognosis(P<0.05).Receiver operating characteristic(ROC)curve analysis revealed that the area under the curve(AUC)for predicting patient prognosis using GP73,MPO3 alone,and their combined detection was 0.803,0.717,and 0.913,respectively.【Conclusion】Serum GP73 and MPO3 levels are correlated with the prognosis of CHB-related HCC patients.The combined detection of these two markers shows a higher predictive efficiency for patient prognosis.