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Aerobic glycolysis enables the effector differentiation potential of stem-like CD4^(+)T cells to combat cancer

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摘要 In 1957,Macfarlane Burnet proposed the theory that harnessing the body’s immune system could be an effective method for cancer treatment[1].Today,T-cell-based immunotherapies have indeed become a vital part of cancer treatment[2].However,a deeper understanding of antitumor immunity is still necessary to further support these treatments.Notably,CD4^(+)T cells are central to mediating antitumor immune responses[3,4,5,6],yet the cellular and molecular programs governing CD4^(+)T-cell antitumor immunity remain unclear.Our recent research revealed that CD4^(+)T-cell immunity is critically dependent on an intrinsic stem-like program[7].
出处 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2024年第5期527-529,共3页 中国免疫学杂志(英文版)
关键词 IMMUNITY CANCER enable
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