一氧化氮在孤独症中作用及调控机制进展

Progress on the role and regulatory mechanism of nitric oxide in autism

一氧化氮(NO)是一种重要的生物信号分子,在人体生理病理中发挥重要作用。孤独症(ASD)是一种复杂的神经发育障碍疾病,目前病因不明。在ASD患者中发现NO水平异常,但NO在ASD病因中发挥怎样的作用尚不清楚。该文综述了NO生理功能,通过ASD的多种致病风险因素探究NO如何参与调控ASD发病机制,从NO对ASD发病机制的调控角度为ASD诊断和治疗提供理论依据。

Nitric oxide(NO)is an important biological signaling molecule,which plays an important role in human physiology and pathology.Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with unknown etiology.At present,abnormal levels of NO have been found in ASD patients,but what role NO plays in the etiology of ASD is still unclear.This article focuses on the physiological function of NO,and explores how NO is involved in the regulation of ASD pathogenesis through a variety of pathogenic risk factors of ASD.Through mechanism exploration,it provides new ideas for the etiology of ASD and new targets for the treatment of ASD.The regulation of NO on the pathogenesis of ASD provides theoretical support for the diagnosis and treatment of ASD.