熊去氧胆酸对胆囊切除术后综合征防治作用分析

Analysis of the Role of Ursodeoxycholic Acid in the Prevention and Treatment of Post-cholecystectomy Syndrome

目的:分析熊去氧胆酸对胆囊切除术后综合征(PCS)的防治作用。方法:选取2022年1—6月大理大学第三附属医院收治的腹腔镜胆囊切除术患者100例为研究对象,采用随机数字表法分为对照组和试验组,各50例。对照组采用术后常规治疗,试验组在对照组基础上采用熊去氧胆酸胶囊治疗。对比两组手术指标、肝功能指标、炎性因子指标及PCS发生率。结果:试验组术后通气时间、术后住院时间短于对照组,术后24h数字评定量表评分低于对照组(P<0.001)。治疗后,两组丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素水平均降低,试验组低于对照组(P<0.05)。治疗后,两组白细胞介素-6、肿瘤坏死因子-α水平降低,试验组低于对照组(P<0.05)。试验组PCS总发生率低于对照组(P=0.007)。结论:熊去氧胆酸对PCS防治作用显著,可改善患者手术指标、肝功能指标、炎性因子指标,降低PCS发生率。

Objective:To analyze the role of ursodeoxycholic acid in the prevention and treatment of post-cholecystectomy syndrome(PCS).Methods:One hundred cases of laparoscopic cholecystectomy patients admitted to the Third Affiliated Hospital of Dali University from January to June 2022 were selected for the study,and were divided into the control group and the experimental group,each with fifty cases,by using the method of randomized numerical table.The control group was treated with postoperative conventional treatment,and the experimental group was treated with ursodeoxycholic acid capsule on the basis of the control group.The surgical indexes,liver function indexes,inflammatory factor indexes and the incidence of PCS were compared between the two groups.Results:The postoperative ventilation time and postoperative hospitalization time of the experimental group were shorter than that of the control group,and the 24-h postoperative numerical rating scale score was lower than that of the control group(P<0.001).After the treatment,the levels of alanine aminotransferase,aspartate aminotransferase,and total bilirubin were reduced in the two groups,and the experimental group was lower than that of the control group(P<0.05).After treatment,the levels of interleukin-6 and tumor necrosis factor-αwere reduced in both groups,and the experimental group was lower than the control group(P<0.05).The total incidence of PCS in the experimental group was lower than the control group(P=0.007).Conclusion:Ursodeoxycholic acid has a significant effect on the prevention and treatment of PCS,which can improve the surgical indexes,hepatic function indexes,inflammatory factor indexes,and reduce the incidence of PCS.