基于SPO语义结构和文献内容特征的免疫性肾病中西医疾病名称关联映射研究

Study on Mapping Disease Name Associations Between Traditional Chinese Medicine and Western Medicine for Immune-mediated Kidney Diseases Using Semantic SPO Structures and Literature Features

目的:基于SPO语义结构和文献内容特征,研究免疫性肾病中西医疾病名称关联映射关系,为推动中西医融合发展提供参考。方法:在SinoMed和CNKI数据库收集自建库起至2022年10月的相关科技文献,以基于文献的知识发现为基础,构造免疫性肾病疾病名称词典并建立完善抽取规则,利用自主研发的中西医疾病名称关联映射工具,融合SPO语义结构表示与“中医称之为”“中医属于”等文献内容特征词,抽取医学文献中的疾病名称和关系,通过专家审核评估,循环迭代优化算法,完成文献中免疫性肾病中西医疾病名称对应关系的深度挖掘。结果:从14752篇科技文献自动抽取出976条与10种特定免疫性肾病相关的中西医疾病名称关联对应关系,人工审核后统计得出准确率(precision)为80.3%、召回率(recall)为98.49%、F值为88.43%。提取出29个特征词,从文献角度发现免疫性肾病与“水肿”“尿血”“虚劳”等关系密切,与“腰痛”等存在联系。结论:免疫性肾病多与中医“水肿”“尿血”“虚劳”关系密切,研究提出的融合SPO语义结构和文献内容特征的中西医疾病名称关联映射方法,能够用于临床诊疗支持。

Objective:This study explores the mapping relationship between disease names in Traditional Chinese Medicine(TCM)and Western Medicine for immune-mediated kidney diseases,based on the integration of SPO semantic structure and literature content characteristics.It aims to provide insights for promoting the integration of Chinese and Western medicine.Methods:The relevant scientific and technological literature was collected from the SinoMed and CNKI databases up to October 2022 since the establishment of the databases.By utilizing literature-based knowledge discovery,we constructed a lexicon of immune-mediated kidney disease names and established extraction rules.Using a self-developed tool,we integrated SPO semantic structures with specific content features,such as"Chinese medicine is called"and"Chinese medicine belongs to",to extract disease names from medical literature.Through iterative algorithm optimization and expert review,we mined deep correspondences between Chinese and Western medical disease names.Results:A total of 976 correspondences between Chinese and Western medical disease names related to 10 specific immune-mediated kidney diseases were automatically extracted from 14752 scientific papers,with an precision of 80.3%,recall of 98.49%,and F-value of 88.43%after manual review.Twenty-nine characteristic words were extracted,revealing that immune-mediated kidney diseases are closely associated with terms such as"edema","blood in urine",and"deficiency syndrome",and have connections to"lumbago".Conclusion:Immune-mediated kidney diseases are closely related to"edema","blood in urine",and"deficiency syndrome"in Traditional Chinese Medicine.The proposed method for mapping Chinese and Western medical disease names through the integration of SPO semantics and literature content features can be applied to clinical practice.