摘要
BACKGROUND The presence of perineural invasion(PNI)in patients with rectal cancer(RC)is associated with significantly poorer outcomes.However,traditional diagnostic modalities have many limitations.AIM To develop a deep learning radiomics stacking nomogram model to predict preoperative PNI status in patients with RC.METHODS We recruited 303 RC patients and separated them into the training(n=242)and test(n=61)datasets on an 8:2 scale.A substantial number of deep learning and hand-crafted radiomics features of primary tumors were extracted from the arterial and venous phases of computed tomography(CT)images.Four machine learning models were used to predict PNI status in RC patients:support vector machine,k-nearest neighbor,logistic regression,and multilayer perceptron.The stacking nomogram was created by combining optimal machine learning models for the arterial and venous phases with predicting clinical variables.RESULTS With an area under the curve(AUC)of 0.964[95%confidence interval(CI):0.944-0.983]in the training dataset and an AUC of 0.955(95%CI:0.900-0.999)in the test dataset,the stacking nomogram demonstrated strong performance in predicting PNI status.In the training dataset,the AUC of the stacking nomogram was greater than that of the arterial support vector machine(ASVM),venous SVM,and CT-T stage models(P<0.05).Although the AUC of the stacking nomogram was greater than that of the ASVM in the test dataset,the difference was not particularly noticeable(P=0.05137).CONCLUSION The developed deep learning radiomics stacking nomogram was effective in predicting preoperative PNI status in RC patients.
