肿瘤相关性胃损伤及保护中国专家整合医学共识(2024版)

Expert consensus on integrated medicine for tumor‐related gastric injury and protection in China(2024 edition)

肿瘤疾病是目前危害人群健康的主要原因之一。随着整合医学理念指导下个体化治疗的不断发展,更多学者开始关注肿瘤相关性副损伤。其中作为人体重要消化分泌器官的胃损伤较为常见。胃具有丰富的血供和神经,其屏障功能可被药物、手术及介入等肿瘤治疗手段损伤,肿瘤自身也可通过多种机制损伤胃,主要表现出胃炎、糜烂、溃疡、出血和穿孔等症状,影响患者生活质量和危及生命。目前,胃肠肿瘤本身及其他系统肿瘤对胃损伤的机制不明,缺乏相关临床和基础研究,其诊断标准及整体防护措施有待补充完善。为进一步提高相关领域人员对肿瘤相关胃损伤及其保护的认识并指导临床工作,在整合医学理念指导下以及在前期中国抗癌协会(CACA)指南基础上,具体细化并制定本专家共识,概述性总结多种肿瘤对胃的损伤及保护治疗策略,旨在为肿瘤领域临床医生在治疗本系统疾病时关注及预防保护胃损伤提供参考,并为未来进一步深入研究奠定基础。

Neoplasm is one of the major causes of harm to human health.With the development of integrated medicine,more experts have begun to pay attention to tumor‐related damage,among which gastric injury is common and seriously affects the quality of life of patients.The stomach is richly supplied with blood and nerves.Tumor treatment methods such as medication,surgery,and interventional therapy can impair its barrier function.Additionally,the tumor itself can harm the stomach through various mechanisms,primarily manifesting as symptoms like gastritis,erosion,ulceration,bleeding,and perforation.These conditions significantly affect the patient's quality of life and pose a serious threat to life.At present,the mechanisms of gastrointestinal tumors and other systemic tumors causing gastric injury are unclear,and there is a lack of relevant clinical and basic research.The diagnostic criteria and protective measures need to be supplemented and improved.To enhance the understanding of tumor-related gastric injuries and their management among professionals in related fields and to guide clinical practice,this expert consensus has been refined and formulated under the integrated medical concepts and based on the previous guidelines of the Chinese Anti-Cancer Association(CACA).It summarizes various tumor-related gastric injuries and protective treatment strategies,aiming to provide clinicians in oncology with a reference to address and prevent gastric injuries during the treatment of systemic diseases,thereby laying a foundation for further in-depth research in the future.